Soluble factors and increase of protein synthesis in regenerating liver

Francesco Cajone; Elisabetta Ferrero; Aldo Bernelli-Zazzera

doi:10.1016/0020-711X(80)90303-1

Soluble factors and increase of protein synthesis in regenerating liver

Francesco Cajone, Elisabetta Ferrero, Aldo Bernelli-Zazzera

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

1. 1. Synthesis of leucyl- and phenylalanyl-tRNA increased under various experimental conditions in cell sap obtained from regenerating rat liver. 2. 2. Activities as well as affinities for the substrates and ATP requirements of leucyl-tRNA synthetase were essentially the same in normal and regenerating livers. 3. 3. The difference between normal and regenerating cell sap disappeared on addition of a large excess of normal tRNAs. 4. 4. The increased amino acid incorporation activity by cell sap from regenerating livers does not seem to depend on concurrent increased activity of amino acyl synthetase, but might be associated with changes in tRNA.

Original language	English
Pages (from-to)	341-346
Number of pages	6
Journal	International Journal of Biochemistry
Volume	11
Issue number	5
DOIs	https://doi.org/10.1016/0020-711X(80)90303-1
Publication status	Published - 1980

ASJC Scopus subject areas

Biochemistry

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title = "Soluble factors and increase of protein synthesis in regenerating liver",

abstract = "1. 1. Synthesis of leucyl- and phenylalanyl-tRNA increased under various experimental conditions in cell sap obtained from regenerating rat liver. 2. 2. Activities as well as affinities for the substrates and ATP requirements of leucyl-tRNA synthetase were essentially the same in normal and regenerating livers. 3. 3. The difference between normal and regenerating cell sap disappeared on addition of a large excess of normal tRNAs. 4. 4. The increased amino acid incorporation activity by cell sap from regenerating livers does not seem to depend on concurrent increased activity of amino acyl synthetase, but might be associated with changes in tRNA.",

author = "Francesco Cajone and Elisabetta Ferrero and Aldo Bernelli-Zazzera",

year = "1980",

doi = "10.1016/0020-711X(80)90303-1",

language = "English",

volume = "11",

pages = "341--346",

journal = "International Journal of Biochemistry",

issn = "0020-711X",

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T1 - Soluble factors and increase of protein synthesis in regenerating liver

AU - Cajone, Francesco

AU - Ferrero, Elisabetta

AU - Bernelli-Zazzera, Aldo

PY - 1980

Y1 - 1980

N2 - 1. 1. Synthesis of leucyl- and phenylalanyl-tRNA increased under various experimental conditions in cell sap obtained from regenerating rat liver. 2. 2. Activities as well as affinities for the substrates and ATP requirements of leucyl-tRNA synthetase were essentially the same in normal and regenerating livers. 3. 3. The difference between normal and regenerating cell sap disappeared on addition of a large excess of normal tRNAs. 4. 4. The increased amino acid incorporation activity by cell sap from regenerating livers does not seem to depend on concurrent increased activity of amino acyl synthetase, but might be associated with changes in tRNA.

AB - 1. 1. Synthesis of leucyl- and phenylalanyl-tRNA increased under various experimental conditions in cell sap obtained from regenerating rat liver. 2. 2. Activities as well as affinities for the substrates and ATP requirements of leucyl-tRNA synthetase were essentially the same in normal and regenerating livers. 3. 3. The difference between normal and regenerating cell sap disappeared on addition of a large excess of normal tRNAs. 4. 4. The increased amino acid incorporation activity by cell sap from regenerating livers does not seem to depend on concurrent increased activity of amino acyl synthetase, but might be associated with changes in tRNA.

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