Soluble HLA class I/CD8 ligation triggers apoptosis in EBV-specific CD8+ cytotoxic T lymphocytes by Fas/Fas-ligand interaction

Paola Contini, Massimo Ghio, Andrea Merlo, Sabrina Brenci, Gilberto Filaci, Francesco Indiveri, Francesco Puppo

Research output: Contribution to journalArticle

Abstract

In the present study, we report that allogeneic soluble HLA class I (sHLA-I) molecules isolated from serum induce apoptosis on EBV-specific CD8+ Fas+ cytotoxic T lymphocytes (CTL). CTL apoptosis is induced by the binding of sHLA-I molecules to CD8 and its extent depends on the time of incubation with sHLA-I molecules. Apoptosis is triggered by the interaction of Fas+ CTL with soluble Fas-ligand, which is released following the binding of sHLA-I antigens to CD8 molecules. These results suggest that sHLA-I molecules may regulate immune responses by inducing apoptosis in virus-specific CTL.

Original languageEnglish
Pages (from-to)1347-1351
Number of pages5
JournalHuman Immunology
Volume61
Issue number12
DOIs
Publication statusPublished - 2000

Keywords

  • Apoptosis
  • CTL
  • EBV
  • Fas/Fas-L
  • HLA

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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