TY - JOUR
T1 - Soluble HLA-G and HLA-A,-B,-C serum levels in patients with allergic rhinitis
AU - Ciprandi, G.
AU - Colombo, B. M.
AU - Contini, P.
AU - Cagnati, P.
AU - Pistorio, A.
AU - Puppo, F.
AU - Murdaca, G.
PY - 2008/10
Y1 - 2008/10
N2 - Background: Allergic rhinitis (AR) is characterized by Th2-polarized immune response. Soluble HLA (sHLA) molecules play an immunomodulatory activity. So far, however, no study investigated them in AR. Objective: The aim of this study was to evaluate sHLA-G and sHLA-A,-B,-C serum levels in AR patients with pollen allergy and in a group of healthy controls. Methods: Forty-nine AR patients were enrolled. A group of healthy nonallergic subjects was considered as control. sHLA-G and sHLA-A,-B,-C serum levels were determined by immunoenzymatic method. The study was conducted during the winter, such as outside the pollen season. Results: Allergic patients had significantly higher levels of both sHLA-G (P <0.0001) and sHLA-A,-B,-C (P = 0.011) molecules than normal controls. Moreover, there was a significant relationship between these two soluble molecules (r = 0.69) in allergic patients. Conclusion: The present study provides the first evidence that both sHLA-G and sHLA-A,-B,-C serum levels are significantly increased in AR patients with pollen allergy.
AB - Background: Allergic rhinitis (AR) is characterized by Th2-polarized immune response. Soluble HLA (sHLA) molecules play an immunomodulatory activity. So far, however, no study investigated them in AR. Objective: The aim of this study was to evaluate sHLA-G and sHLA-A,-B,-C serum levels in AR patients with pollen allergy and in a group of healthy controls. Methods: Forty-nine AR patients were enrolled. A group of healthy nonallergic subjects was considered as control. sHLA-G and sHLA-A,-B,-C serum levels were determined by immunoenzymatic method. The study was conducted during the winter, such as outside the pollen season. Results: Allergic patients had significantly higher levels of both sHLA-G (P <0.0001) and sHLA-A,-B,-C (P = 0.011) molecules than normal controls. Moreover, there was a significant relationship between these two soluble molecules (r = 0.69) in allergic patients. Conclusion: The present study provides the first evidence that both sHLA-G and sHLA-A,-B,-C serum levels are significantly increased in AR patients with pollen allergy.
KW - Allergic rhinitis
KW - Pollens
KW - sHLA-A,-B,-C
KW - sHLA-G
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UR - http://www.scopus.com/inward/citedby.url?scp=51349153254&partnerID=8YFLogxK
U2 - 10.1111/j.1398-9995.2008.01741.x
DO - 10.1111/j.1398-9995.2008.01741.x
M3 - Article
C2 - 18782112
AN - SCOPUS:51349153254
VL - 63
SP - 1335
EP - 1338
JO - Allergy: European Journal of Allergy and Clinical Immunology
JF - Allergy: European Journal of Allergy and Clinical Immunology
SN - 0105-4538
IS - 10
ER -