Soluble HLA-G concentrations in maternal blood and cervical vaginal fluid of pregnant women with preterm premature rupture of membranes

Fausta Beneventi, Elena Locatelli, Mara De Amici, Margherita Simonetta, Chiara Cavagnoli, Camilla Bellingeri, Chiara Scancarello, Antonio Maria Ierullo, Miryam Martinetti, Arsenio Spinillo

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To evaluate soluble HLA-G (sHLA-G) concentrations in maternal blood serum and cervical vaginal fluid in pregnancies complicated by preterm premature rupture of membranes (PPROM) compared to controls. Study design: Case-control study of 24 women with PPROM and 40 controls. Main outcome measures: Vaginal and serum sHLA-G and IL-6 concentrations. Findings: Women with PPROM had significantly higher serum and vaginal sHLA-G concentrations compared to controls (respectively median 31.48 U\ml versus 13.9 U\ml p <0.001 and 1.7 U\ml versus 0.1 U\ml p <0.001). Vaginal expression of IL-6 was higher in PPROM cases compared to controls (respectively, median 31.19 pg\ml versus 6.67 pg\ml; p <0.001). Higher serum and vaginal sHLA-G were associated with both a shorter length of pregnancy and histological chorioamnionitis in the PPROM group. Conclusions: Higher vaginal and serum sHLA-G in PPROM cases may be a sign of local and systemic inflammation.

Original languageEnglish
Pages (from-to)76-80
Number of pages5
JournalJournal of Reproductive Immunology
Volume116
DOIs
Publication statusPublished - Aug 1 2016

Keywords

  • IL-6
  • Preterm premature rupture of membranes
  • Vaginal and serum sHLA-G

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Obstetrics and Gynaecology
  • Reproductive Medicine

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