Soluble HLA-G molecule in patients with perennial allergic rhinitis

Giorgio Ciprandi, Paola Contini, Giuseppe Murdaca, Anna Maria Gallina, Francesco Puppo

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Allergic rhinitis (AR) is characterized by T helper 2 polarized immune response. The soluble HLA-G (sHLA-G) molecule has an immunomodulatory activity. However, so far, no study has investigated this activity in perennial AR (PAR). Objective: The aim of this study was to evaluate serum sHLA-G levels in PAR patients and in a group of healthy controls. Methods: Twenty-five PAR patients were enrolled. A group of 50 healthy non-allergic subjects was considered as control. sHLA-G serum levels were determined by immunoenzymatic method. Results:Allergic patients had significantly higher levels of the sHLA-G (p <0.001) molecule than normal controls. Moreover, there was a very strong correlation between sHLA-G and symptom severity and drug use (r = 0.85 and 0.793, respectively). Conclusion: The present study provides first evidence that serum sHLA-G levels are significantly increased in PAR patients. Moreover, sHLA-G might be considered as a biomarker for assessing clinical severity.

Original languageEnglish
Pages (from-to)278-281
Number of pages4
JournalInternational Archives of Allergy and Immunology
Volume150
Issue number3
DOIs
Publication statusPublished - Oct 2009

Keywords

  • Allergic rhinitis
  • Perennial allergens
  • Soluble HLA-G

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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