Abstract
Background: Allergic rhinitis (AR) is characterized by T helper 2 polarized immune response. The soluble HLA-G (sHLA-G) molecule has an immunomodulatory activity. However, so far, no study has investigated this activity in perennial AR (PAR). Objective: The aim of this study was to evaluate serum sHLA-G levels in PAR patients and in a group of healthy controls. Methods: Twenty-five PAR patients were enrolled. A group of 50 healthy non-allergic subjects was considered as control. sHLA-G serum levels were determined by immunoenzymatic method. Results:Allergic patients had significantly higher levels of the sHLA-G (p <0.001) molecule than normal controls. Moreover, there was a very strong correlation between sHLA-G and symptom severity and drug use (r = 0.85 and 0.793, respectively). Conclusion: The present study provides first evidence that serum sHLA-G levels are significantly increased in PAR patients. Moreover, sHLA-G might be considered as a biomarker for assessing clinical severity.
Original language | English |
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Pages (from-to) | 278-281 |
Number of pages | 4 |
Journal | International Archives of Allergy and Immunology |
Volume | 150 |
Issue number | 3 |
DOIs | |
Publication status | Published - Oct 2009 |
Keywords
- Allergic rhinitis
- Perennial allergens
- Soluble HLA-G
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology