Soluble intercellular adhesion molecule-1 serum profile in physiologic and preeclamptic pregnancy

Lucia Airoldi, Barbara Gaffuri, Gabriele Rossi, Enrico Iurlaro, Arrigo Nozza, Paola Vigano, Mario Vignali

Research output: Contribution to journalArticle

Abstract

PROBLEM: The aim of this study was to determine serum levels of soluble intercellular adhesion molecule (sICAM)-1, an adhesion receptor that mediates interactions with the immune system, in physiologic and preeclamptic pregnancies. Moreover, we evaluated whether the release of sICAM-1 during pregnancy correlated to plasma fibronectin concentrations. METHOD OF STUDY: Serum was collected from 18 nonpregnant, control women, from 58 normal pregnant women during the first (n = 13), second (n = 15), and third (n = 30) trimesters, and from 25 preeclamptic patients at 27-39 weeks' gestation. All samples were assayed for sICAM-1 by a specific enzyme-linked immunoassay and for fibronectin by a nephelometric system. Serum sICAM-1 levels in preeclamptic patients were compared to those obtained from gestational matched normal pregnant women. RESULTS: Levels of sICAM-1 were significantly elevated (P <0.001) in each of the three trimesters of normal pregnancy (I trimester: 390.4 ± 25.7 ng/ml; II trimester: 386.3 ± 15.4 ng/ml; and III trimester: 367.3 ± 15.8 ng/ml) when compared to those of healthy nonpregnant women (263.3 ± 11.6 ng/ml). No significant difference in sICAM-1 concentrations was observed among the three trimesters. Preeclampsia was associated to a significant decrease (P <0.01) of sICAM-1 levels (309.8 ± 11.6 ng/ml) relative to those observed in gestational-matched pregnant women (367.3 ± 15.8 ng/ml). Fibronectin and sICAM-1 levels did not correlate. CONCLUSION: The increased levels of sICAM-1 found in physiologic pregnancies and its reduction in preeclampsia may account for some of the immunologic alterations demonstrated to be associated with pregnancy.

Original languageEnglish
Pages (from-to)183-188
Number of pages6
JournalAmerican Journal of Reproductive Immunology
Volume39
Issue number3
Publication statusPublished - 1998

Fingerprint

Intercellular Adhesion Molecule-1
Pregnancy
Serum
Fibronectins
Pregnant Women
Pre-Eclampsia
Pregnancy Trimesters
Immunoenzyme Techniques
Immune System

Keywords

  • Fibronectin
  • Preeclampsia
  • Pregnancy
  • Soluble intercellular adhesion molecule (sICAM)-1

ASJC Scopus subject areas

  • Immunology
  • Obstetrics and Gynaecology

Cite this

Airoldi, L., Gaffuri, B., Rossi, G., Iurlaro, E., Nozza, A., Vigano, P., & Vignali, M. (1998). Soluble intercellular adhesion molecule-1 serum profile in physiologic and preeclamptic pregnancy. American Journal of Reproductive Immunology, 39(3), 183-188.

Soluble intercellular adhesion molecule-1 serum profile in physiologic and preeclamptic pregnancy. / Airoldi, Lucia; Gaffuri, Barbara; Rossi, Gabriele; Iurlaro, Enrico; Nozza, Arrigo; Vigano, Paola; Vignali, Mario.

In: American Journal of Reproductive Immunology, Vol. 39, No. 3, 1998, p. 183-188.

Research output: Contribution to journalArticle

Airoldi, L, Gaffuri, B, Rossi, G, Iurlaro, E, Nozza, A, Vigano, P & Vignali, M 1998, 'Soluble intercellular adhesion molecule-1 serum profile in physiologic and preeclamptic pregnancy', American Journal of Reproductive Immunology, vol. 39, no. 3, pp. 183-188.
Airoldi, Lucia ; Gaffuri, Barbara ; Rossi, Gabriele ; Iurlaro, Enrico ; Nozza, Arrigo ; Vigano, Paola ; Vignali, Mario. / Soluble intercellular adhesion molecule-1 serum profile in physiologic and preeclamptic pregnancy. In: American Journal of Reproductive Immunology. 1998 ; Vol. 39, No. 3. pp. 183-188.
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AU - Vigano, Paola

AU - Vignali, Mario

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