Soluble interleukin-2 receptor, interleukin-2 and interleukin-4 in sera and supernatants from patients with progressive systemic sclerosis

G. Famularo, A. Procopio, R. Giacomelli, C. Danese, S. Sacchetti, M. A. Perego, A. Santoni, G. Tonietti

Research output: Contribution to journalArticlepeer-review

Abstract

We studied the sera of patients with progressive systemic sclerosis (PSS) for elevated levels of soluble interleukin-2 receptor (sIL-2R), interleukin-2 (IL-2) and interleukin-4 (IL-4). We also measured Il-2, IL-4 and B cell growth factor (BCGF) activity in supernatants of peripheral blood mononuclear cells from the same patients. The finding of elevated serum sIL-2R and IL-2, and the increased levels of IL-2, IL-4 and BCGF activity in culture supernatants indicates that T lymphocyte hyperactivity likely play a major role in PSS. The failure to detect under our experimental conditions a direct proliferative effect of recombinant IL-2 on enriched normal B cells might suggest that IL-4 is the cytokine mainly responsible of the BCGF activity recovered in PSS supernatants.

Original languageEnglish
Pages (from-to)368-372
Number of pages5
JournalClinical and Experimental Immunology
Volume81
Issue number3
Publication statusPublished - 1990

Keywords

  • B cell growth factor activity
  • Interleukin-2
  • Interleukin-4
  • Progressive systemic sclerosis
  • Soluble interleukin-2 receptor

ASJC Scopus subject areas

  • Immunology

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