Effetto immunomodulatorio delle emotrasfusioni e delle immunoglobuline per via endovenosa

Ruolo delle molecole del complesso maggiore di istocompatibilita di classe I e Fas-ligando solubili

Translated title of the contribution: Soluble major histocompatibility complex class I and Fas-ligand molecules in blood components and intravenous immunoglobulins: Their role in the immunomodulatory effects of blood transfusions

M. Ghio, P. Contini, F. Puppo, F. Indiveri

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Allogeneic blood transfusions may have immunomodulatory effects including improved allograft acceptance and increased risk for cancer recurrence or post-operative bacterial infections. These effects are associated with the presence of leukocytes in transfused blood and are reduced by prestorage leukoreduction. However, the precise mechanism of this effect has not yet been elucidated. We report that the concentrations of soluble major histocompatibility complex class I and soluble Fas-ligand molecules are significantly higher in supernatants of blood components containing elevated numbers of residual donor leukocytes, such as red blood cells and random-donor platelets, than in other blood components. Elevated amounts of soluble Fas-ligand molecules are also found in some intravenous immunoglobulin preparations. Soluble molecules detected in blood components and in immunoglobulin preparations are biologically active in vitro. In fact, they inhibit mixed lymphocyte responses and cytotoxic T cell activity in allogeneic and autologous combinations and induce apoptosis in Fas-positive cells. These results should be taken into account in clinical practice to select the blood component or the immunoglobulin preparation in order to induce or prevent an immunosuppressive effect in the recipient.

Original languageItalian
Pages (from-to)70-74
Number of pages5
JournalAnnali Italiani di Medicina Interna
Volume15
Issue number1
Publication statusPublished - 2000

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Fas Ligand Protein
Intravenous Immunoglobulins
Major Histocompatibility Complex
Blood Transfusion
Immunoglobulins
Leukocytes
Immunosuppressive Agents
Bacterial Infections
Allografts
Blood Platelets
Erythrocytes
Lymphocytes
Apoptosis
T-Lymphocytes
Recurrence
Neoplasms

ASJC Scopus subject areas

  • Internal Medicine

Cite this

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title = "Effetto immunomodulatorio delle emotrasfusioni e delle immunoglobuline per via endovenosa: Ruolo delle molecole del complesso maggiore di istocompatibilita di classe I e Fas-ligando solubili",
abstract = "Allogeneic blood transfusions may have immunomodulatory effects including improved allograft acceptance and increased risk for cancer recurrence or post-operative bacterial infections. These effects are associated with the presence of leukocytes in transfused blood and are reduced by prestorage leukoreduction. However, the precise mechanism of this effect has not yet been elucidated. We report that the concentrations of soluble major histocompatibility complex class I and soluble Fas-ligand molecules are significantly higher in supernatants of blood components containing elevated numbers of residual donor leukocytes, such as red blood cells and random-donor platelets, than in other blood components. Elevated amounts of soluble Fas-ligand molecules are also found in some intravenous immunoglobulin preparations. Soluble molecules detected in blood components and in immunoglobulin preparations are biologically active in vitro. In fact, they inhibit mixed lymphocyte responses and cytotoxic T cell activity in allogeneic and autologous combinations and induce apoptosis in Fas-positive cells. These results should be taken into account in clinical practice to select the blood component or the immunoglobulin preparation in order to induce or prevent an immunosuppressive effect in the recipient.",
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AU - Contini, P.

AU - Puppo, F.

AU - Indiveri, F.

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AB - Allogeneic blood transfusions may have immunomodulatory effects including improved allograft acceptance and increased risk for cancer recurrence or post-operative bacterial infections. These effects are associated with the presence of leukocytes in transfused blood and are reduced by prestorage leukoreduction. However, the precise mechanism of this effect has not yet been elucidated. We report that the concentrations of soluble major histocompatibility complex class I and soluble Fas-ligand molecules are significantly higher in supernatants of blood components containing elevated numbers of residual donor leukocytes, such as red blood cells and random-donor platelets, than in other blood components. Elevated amounts of soluble Fas-ligand molecules are also found in some intravenous immunoglobulin preparations. Soluble molecules detected in blood components and in immunoglobulin preparations are biologically active in vitro. In fact, they inhibit mixed lymphocyte responses and cytotoxic T cell activity in allogeneic and autologous combinations and induce apoptosis in Fas-positive cells. These results should be taken into account in clinical practice to select the blood component or the immunoglobulin preparation in order to induce or prevent an immunosuppressive effect in the recipient.

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