Soluble P-selectin and proinflammatory cytokines in patients with polygenic type IIa hypercholesterolemia

Patrizia Ferroni, Stefania Basili, Marco Vieri, Francesca Martini, Giancarlo Labbadia, Ada Bellomo, Pier Paolo Gazzaniga, Corrado Cordova, Cesare Alessandri

Research output: Contribution to journalArticle

Abstract

Plasma soluble P-selectin (sP-selectin), β-thromboglobulin (β-TG), von Willebrand Factor (vWF), prothrombin factor 1+2 (F1+2), IL-6 and IL-1β levels were analyzed in 35 consecutive patients with polygenic type IIa hypercholesterolemia (HC) and 35 age- and sex-matched healthy subjects. sP- selectin (p 0.005), β-TG (p <0.05) and IL-1β (p <0.02) levels were higher in HC patients than healthy subjects whereas no significant difference was observed for vWF. sP-selectin directly correlated with β-TG (p <0.05) and IL-1β levels (p <0.005), but not with the other variables analyzed. A direct correlation was observed between F1+2 and IL-6 (p <0.05), total cholesterol (p <0.05) or LDL cholesterol (p 0.05). We conclude that HC is associated with an increase of plasma sP-selectin levels, and that sP- selectin may be considered as a marker of in vivo platelet activation in type IIa polygenic HC. The correlations observed among the variables analyzed in the study suggest that proinflammatory cytokines might play a role in the prothrombotic state often associated with HC. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)277-285
Number of pages9
JournalHaemostasis
Volume29
Issue number5
Publication statusPublished - Mar 2000

Keywords

  • Cytokines
  • Fibrinogen
  • Hypercholesterolemia
  • IL-1β
  • IL-6
  • P-selectin
  • Prothrombin fragment 1+2

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Ferroni, P., Basili, S., Vieri, M., Martini, F., Labbadia, G., Bellomo, A., Gazzaniga, P. P., Cordova, C., & Alessandri, C. (2000). Soluble P-selectin and proinflammatory cytokines in patients with polygenic type IIa hypercholesterolemia. Haemostasis, 29(5), 277-285.