Soluble P-selectin as a marker of in vivo platelet activation

Patrizia Ferroni, Francesca Martini, Silvia Riondino, Francesca La Farina, Agesilao Magnapera, Filippo Ciatti, Fiorella Guadagni

Research output: Contribution to journalArticle

Abstract

Background: Platelets are the major source of circulating sP-selectin. Elevated levels of this protein have been found in many atherothrombotic disorders. Thus, we investigated whether sP-selectin dosage might reflect platelet function in patients with risk factors for or with established cardiovascular diseases and whether its levels can be modulated by aspirin therapy. Methods: Plasma sP-selectin levels and light transmission platelet aggregometry (LTA) were analyzed in 152 outpatients. The effects of a 6-month aspirin therapeutic course on sP-selectin levels and LTA in 51 consecutive patients have been also investigated. Results: Significant correlations were observed between sP-selectin and Mx% LTA in response to epinephrine (p = 0.022) and arachidonic acid (p = 0.006), or between sP-selectin and collagen lag-phase (p = 0.016). Multiple regression analysis showed that the only predictors of sP-selectin levels were platelet number (p <0.001) and collagen-induced lag-phase (p <0.01). Aspirin-treated patients showed a significant reduction of sP-selectin levels by 13% (p = 0.021) which significantly correlated with collagen-induced lag-phase (p = 0.005). Conclusions: sP-selectin dosage could be proposed as a reliable marker of platelet activation in patients with major atherosclerotic risk factors either in the absence of clinically overt disease, and might represent a valid tool to asses in vivo platelet behavior.

Original languageEnglish
Pages (from-to)88-91
Number of pages4
JournalClinica Chimica Acta
Volume399
Issue number1-2
DOIs
Publication statusPublished - Jan 2009

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Keywords

  • Antiplatelet drugs
  • Platelet aggregation
  • Soluble P-selectin

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

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