Soluble selectin levels in patients with lung cancer

M. Roselli, T. C. Mineo, F. Martini, S. Mariotti, V. Ambrogi, A. Spila, R. D'Alessandro, S. Basili, F. Guadagni, Patrizia Ferroni

Research output: Contribution to journalArticlepeer-review

Abstract

Increased expression of selectins has been found on endothelial cells of venules and capillaries in the tumor stroma of non-small cell lung cancer, suggesting their functional role in the process of chemotaxis for tumor cells. The present study was aimed at analyzing the role of both soluble (s)P-selectin and sE-selectin levels in association with clinicopathological variables in 116 patients with lung cancer, 38 patients with benign diseases and 59 healthy donors. The results obtained showed that sP-selectin and sE-selectin levels were higher in patients with lung cancer compared to normal donors (p

Original languageEnglish
Pages (from-to)56-62
Number of pages7
JournalInternational Journal of Biological Markers
Volume17
Issue number1
Publication statusPublished - 2002

Keywords

  • E-selectin
  • Lung cancer
  • Metastasis
  • P-selectin
  • Soluble adhesion molecule

ASJC Scopus subject areas

  • Immunology
  • Biochemistry

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