Soluble transferrin receptor as a potential determinant of iron loading in congenital anaemias due to ineffective erythropoiesis

Mario Cazzola, Yves Beguin, Gaetano Bergamaschi, Roberta Guarnone, Paola Cerani, Susanna Barella, Antonio Cao, Renzo Galanello

Research output: Contribution to journalArticle

Abstract

Congenital anaemias due to ineffective erythropoiesis may be associated with excessive iron absorption and progressive iron loading. We investigated whether the soluble transferrin receptor (TfR) level was related to the degree of iron overload in 20 patients with thalassaemia intermedia, six patients with congenital dyserythropoietic anaemia type II (CDA II) and four patients with X-linked congenital sideroblastic anaemia (XLSA). All but two patients had increased serum ferritin levels (median 601 μg/l, range 105- 2855 μg/l). Multiple regression analysis showed that 62% (P <0.0001) of the variation in serum ferritin was explained by age and by changes in soluble TfR.

Original languageEnglish
Pages (from-to)752-755
Number of pages4
JournalBritish Journal of Haematology
Volume106
Issue number3
DOIs
Publication statusPublished - 1999

Keywords

  • Anaemia
  • Erythropoiesis
  • Erythropoietin
  • Iron overload
  • Soluble transferrin receptor

ASJC Scopus subject areas

  • Hematology

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