The solution structure of the wild-type A box of rat HMG1 has been determined by heteronuclear three-dimensional NMR and molecular modelling. This structure adopts a "L" shape structure globaly similar to that described for a mutant A box and other HMG boxes. However the wild-type A box contains two Cys residues which could form an intramolecular bridge in an oxidative environment. This should be into competition with a contribution of the thiol groups in the binding of HMG proteins to cisplatin-modified DNA.
|Number of pages||8|
|Journal||Protein and Peptide Letters|
|Publication status||Published - 1997|
ASJC Scopus subject areas
- Molecular Biology