Solution structure of the wild-type HMG1 a box by1H and15N NMR and molecular modelling

Y. Ohyama, P. Sodano, D. Locker, M. E. Bianchi, M. Leng, F. Vovelle, M. Ptak

Research output: Contribution to journalArticlepeer-review

Abstract

The solution structure of the wild-type A box of rat HMG1 has been determined by heteronuclear three-dimensional NMR and molecular modelling. This structure adopts a "L" shape structure globaly similar to that described for a mutant A box and other HMG boxes. However the wild-type A box contains two Cys residues which could form an intramolecular bridge in an oxidative environment. This should be into competition with a contribution of the thiol groups in the binding of HMG proteins to cisplatin-modified DNA.

Original languageEnglish
Pages (from-to)107-114
Number of pages8
JournalProtein and Peptide Letters
Volume4
Issue number2
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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