SOM230, a new somatostatin analogue, is highly effective in the therapy of growth hormone/prolactin-secreting pituitary adenomas

Monica Fedele, Ivana De Martino, Rosario Pivonello, Andrea Ciarmiello, M. Laura Del Basso De Caro, Rosa Visone, Dario Palmieri, Giovanna M. Pierantoni, Claudio Arra, Herbert A. Schmid, Leo Hofland, Gaetano Lombardi, Annamaria Colao, Alfredo Fusco

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: We have previously shown that transgenic mice ubiquitously overexpressing the HMGA2 gene develop growth hormone/prolactin-secreting pituitary adenomas. This animal model has been used to evaluate the therapeutic efficacy of SOM230, a somatostatin analogue with high affinity for the somatostatin receptor subtypes 1, 2, 3, and 5, on the growth of the pituitary adenomas. Experimental Design: Four groups of 3- and 9-month-old HMGA2 transgenic mice were treated for 3 months with a continuous s.c. injection of two different dosages of SOM230 (5 or 50 μg/kg/h), one dose of octreotide, corresponding to that used in human therapy, and a placebo, respectively. The development of the tumor before and after therapy was monitored by magnetic resonance imaging of the pituitary region and evaluation of the serum prolactin levels. Results: The highest dose of SOM230 induced a drastic regression of the tumor, whereas octreotide was not able to induce any significant tumor regression, although tumor progression was significantly slowed down. No significant differences were observed between the animals treated with the lowest dose of SOM230 and those receiving placebo. Conclusions: These results clearly support the efficacy of the SOM230 treatment in human pituitary adenomas secreting prolactin based on the dramatic tumor shrinkage and fall in prolactin levels. This beneficial effect could be of crucial clinical usefulness in patients bearing tumors resistant to dopaminergic drugs.

Original languageEnglish
Pages (from-to)2738-2744
Number of pages7
JournalClinical Cancer Research
Volume13
Issue number9
DOIs
Publication statusPublished - May 1 2007

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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