Somatic and autonomic small fiber neuropathy induced by bortezomib therapy: An immunofluorescence study

Maria Pia Giannoccaro, Vincenzo Donadio, Carolina Gomis Pèrez, Walter Borsini, Vitantonio Di Stasi, Rocco Liguori

Research output: Contribution to journalArticle

Abstract

Bortezomib is a new chemotherapeutic agent approved for the treatment of relapsed/refractory and newly diagnosed multiple myeloma. One of the major side effects of bortezomib is a peripheral length-dependent sensory axonal neuropathy and, less frequently, a small fiber neuropathy. Autonomic symptoms like postural dizziness, syncope, diarrhoea, ileus, impotence and urinary disturbances have been reported, nevertheless, autonomic neuropathy has never been characterized. We describe by means of immunofluorescence, the involvement of autonomic skin nerve fibers in three patients with small fiber neuropathy induced by bortezomib treatment.

Original languageEnglish
Pages (from-to)361-363
Number of pages3
JournalNeurological Sciences
Volume32
Issue number2
DOIs
Publication statusPublished - Apr 2011

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Keywords

  • Autonomic neuropathy
  • Bortezomib
  • Skin biopsy
  • Small fiber neuropathy
  • Velcade

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology

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