Somatic and autonomic small fiber neuropathy induced by bortezomib therapy: An immunofluorescence study

Maria Pia Giannoccaro; Vincenzo Donadio; Carolina Gomis Pèrez; Walter Borsini; Vitantonio Di Stasi; Rocco Liguori

doi:10.1007/s10072-010-0475-2

Somatic and autonomic small fiber neuropathy induced by bortezomib therapy: An immunofluorescence study

Maria Pia Giannoccaro, Vincenzo Donadio, Carolina Gomis Pèrez, Walter Borsini, Vitantonio Di Stasi, Rocco Liguori

Istituto Scienze Neurologiche

Research output: Contribution to journal › Article › peer-review

Abstract

Bortezomib is a new chemotherapeutic agent approved for the treatment of relapsed/refractory and newly diagnosed multiple myeloma. One of the major side effects of bortezomib is a peripheral length-dependent sensory axonal neuropathy and, less frequently, a small fiber neuropathy. Autonomic symptoms like postural dizziness, syncope, diarrhoea, ileus, impotence and urinary disturbances have been reported, nevertheless, autonomic neuropathy has never been characterized. We describe by means of immunofluorescence, the involvement of autonomic skin nerve fibers in three patients with small fiber neuropathy induced by bortezomib treatment.

Original language	English
Pages (from-to)	361-363
Number of pages	3
Journal	Neurological Sciences
Volume	32
Issue number	2
DOIs	https://doi.org/10.1007/s10072-010-0475-2
Publication status	Published - Apr 2011

Keywords

Autonomic neuropathy
Bortezomib
Skin biopsy
Small fiber neuropathy
Velcade

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health
Dermatology

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10.1007/s10072-010-0475-2

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abstract = "Bortezomib is a new chemotherapeutic agent approved for the treatment of relapsed/refractory and newly diagnosed multiple myeloma. One of the major side effects of bortezomib is a peripheral length-dependent sensory axonal neuropathy and, less frequently, a small fiber neuropathy. Autonomic symptoms like postural dizziness, syncope, diarrhoea, ileus, impotence and urinary disturbances have been reported, nevertheless, autonomic neuropathy has never been characterized. We describe by means of immunofluorescence, the involvement of autonomic skin nerve fibers in three patients with small fiber neuropathy induced by bortezomib treatment.",

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AU - Giannoccaro, Maria Pia

AU - Donadio, Vincenzo

AU - Gomis Pèrez, Carolina

AU - Borsini, Walter

AU - Di Stasi, Vitantonio

AU - Liguori, Rocco

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AB - Bortezomib is a new chemotherapeutic agent approved for the treatment of relapsed/refractory and newly diagnosed multiple myeloma. One of the major side effects of bortezomib is a peripheral length-dependent sensory axonal neuropathy and, less frequently, a small fiber neuropathy. Autonomic symptoms like postural dizziness, syncope, diarrhoea, ileus, impotence and urinary disturbances have been reported, nevertheless, autonomic neuropathy has never been characterized. We describe by means of immunofluorescence, the involvement of autonomic skin nerve fibers in three patients with small fiber neuropathy induced by bortezomib treatment.

KW - Autonomic neuropathy

KW - Bortezomib

KW - Skin biopsy

KW - Small fiber neuropathy

KW - Velcade

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Somatic and autonomic small fiber neuropathy induced by bortezomib therapy: An immunofluorescence study

Abstract

Keywords

ASJC Scopus subject areas

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