Abstract
Bortezomib is a new chemotherapeutic agent approved for the treatment of relapsed/refractory and newly diagnosed multiple myeloma. One of the major side effects of bortezomib is a peripheral length-dependent sensory axonal neuropathy and, less frequently, a small fiber neuropathy. Autonomic symptoms like postural dizziness, syncope, diarrhoea, ileus, impotence and urinary disturbances have been reported, nevertheless, autonomic neuropathy has never been characterized. We describe by means of immunofluorescence, the involvement of autonomic skin nerve fibers in three patients with small fiber neuropathy induced by bortezomib treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 361-363 |
| Number of pages | 3 |
| Journal | Neurological Sciences |
| Volume | 32 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Apr 2011 |
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Keywords
- Autonomic neuropathy
- Bortezomib
- Skin biopsy
- Small fiber neuropathy
- Velcade
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health
- Dermatology
Cite this
Somatic and autonomic small fiber neuropathy induced by bortezomib therapy : An immunofluorescence study. / Giannoccaro, Maria Pia; Donadio, Vincenzo; Gomis Pèrez, Carolina; Borsini, Walter; Di Stasi, Vitantonio; Liguori, Rocco.
In: Neurological Sciences, Vol. 32, No. 2, 04.2011, p. 361-363.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Somatic and autonomic small fiber neuropathy induced by bortezomib therapy
T2 - An immunofluorescence study
AU - Giannoccaro, Maria Pia
AU - Donadio, Vincenzo
AU - Gomis Pèrez, Carolina
AU - Borsini, Walter
AU - Di Stasi, Vitantonio
AU - Liguori, Rocco
PY - 2011/4
Y1 - 2011/4
N2 - Bortezomib is a new chemotherapeutic agent approved for the treatment of relapsed/refractory and newly diagnosed multiple myeloma. One of the major side effects of bortezomib is a peripheral length-dependent sensory axonal neuropathy and, less frequently, a small fiber neuropathy. Autonomic symptoms like postural dizziness, syncope, diarrhoea, ileus, impotence and urinary disturbances have been reported, nevertheless, autonomic neuropathy has never been characterized. We describe by means of immunofluorescence, the involvement of autonomic skin nerve fibers in three patients with small fiber neuropathy induced by bortezomib treatment.
AB - Bortezomib is a new chemotherapeutic agent approved for the treatment of relapsed/refractory and newly diagnosed multiple myeloma. One of the major side effects of bortezomib is a peripheral length-dependent sensory axonal neuropathy and, less frequently, a small fiber neuropathy. Autonomic symptoms like postural dizziness, syncope, diarrhoea, ileus, impotence and urinary disturbances have been reported, nevertheless, autonomic neuropathy has never been characterized. We describe by means of immunofluorescence, the involvement of autonomic skin nerve fibers in three patients with small fiber neuropathy induced by bortezomib treatment.
KW - Autonomic neuropathy
KW - Bortezomib
KW - Skin biopsy
KW - Small fiber neuropathy
KW - Velcade
UR - http://www.scopus.com/inward/record.url?scp=79952898848&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952898848&partnerID=8YFLogxK
U2 - 10.1007/s10072-010-0475-2
DO - 10.1007/s10072-010-0475-2
M3 - Article
VL - 32
SP - 361
EP - 363
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 2
ER -