Somatosensory mismatch negativity in healthy children

Domenico Restuccia, Sergio Zanini, Monica Cazzagon, Ivana Del Piero, Lucia Martucci, Giacomo Della Marca

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Aim: Event-related potentials (ERPs) obtained when focused attention is kept away from the stimulus (unnoticed stimulation) are possibly linked to automatic mismatch-detection mechanisms, and could be a useful tool to investigate sensory discrimination ability. By considering the high impact of impaired somatosensory integration on many neurological disturbances in children, we aimed to verify whether mismatch-related responses to somatosensory stimulation could be obtained in healthy children. Method: Eleven healthy participants (age range 6-11y, mean 8y 2mo, SD 1y 7mo; seven males, four females) underwent 'oddball' electrical stimulation of the right hand (80% frequent stimuli delivered to the thumb, 20% deviant stimuli delivered to the fifth finger). Data were compared with those obtained when the frequent stimuli to the thumb were omitted ('standard-omitted' protocol). ERPs were recorded at frontal, central, and parietal scalp locations. Children's overt attention was engaged by a demanding video game. Results: In the oddball protocol, deviant stimulation elicited a left central negativity at about 160ms latency, followed by a left frontal negative response at about 220ms latency. Standard-omitted traces showed only a left parietal negative response spreading to right parietal regions. Interpretation: Mismatch-related somatosensory responses can be reliably obtained in children, providing that appropriate technical contrivances are used. In clinical use, the frontal components, which are present only during the oddball protocol, could be a reliable and unequivocal neurophysiological marker of the automatic mismatch-detection mechanism.

Original languageEnglish
Pages (from-to)991-998
Number of pages8
JournalDevelopmental Medicine and Child Neurology
Volume51
Issue number12
DOIs
Publication statusPublished - 2009

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Thumb
Evoked Potentials
Video Games
Parietal Lobe
Scalp
Electric Stimulation
Fingers
Healthy Volunteers
Hand
caN protocol

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience

Cite this

Restuccia, D., Zanini, S., Cazzagon, M., Del Piero, I., Martucci, L., & Della Marca, G. (2009). Somatosensory mismatch negativity in healthy children. Developmental Medicine and Child Neurology, 51(12), 991-998. https://doi.org/10.1111/j.1469-8749.2009.03367.x

Somatosensory mismatch negativity in healthy children. / Restuccia, Domenico; Zanini, Sergio; Cazzagon, Monica; Del Piero, Ivana; Martucci, Lucia; Della Marca, Giacomo.

In: Developmental Medicine and Child Neurology, Vol. 51, No. 12, 2009, p. 991-998.

Research output: Contribution to journalArticle

Restuccia, D, Zanini, S, Cazzagon, M, Del Piero, I, Martucci, L & Della Marca, G 2009, 'Somatosensory mismatch negativity in healthy children', Developmental Medicine and Child Neurology, vol. 51, no. 12, pp. 991-998. https://doi.org/10.1111/j.1469-8749.2009.03367.x
Restuccia, Domenico ; Zanini, Sergio ; Cazzagon, Monica ; Del Piero, Ivana ; Martucci, Lucia ; Della Marca, Giacomo. / Somatosensory mismatch negativity in healthy children. In: Developmental Medicine and Child Neurology. 2009 ; Vol. 51, No. 12. pp. 991-998.
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