Somatosensory pathway dysfunction in uremic children

A. Suppiej, G. Caara, C. Boniver, G. B. Pozzan, G. Montini, G. F. Zacchello Zacchello

Research output: Contribution to journalArticlepeer-review

Abstract

Neurophysiological studies have shown defects in peripheral conduction in up to 75% of adults with end-stage renal disease (ESRD), though abnormalities of central conduction seem more variable. There are no comparable pediatric data. We therefore measured median nerve somatosensory evoked potentials (SEPs) in 10 children with ESRD, maintained by hemodialysis, who had no neurological signs or symptoms, and compared the results with those for age-matched controls. The latencies of N9, P14, N20 and P22, and interpeak latencies, N9-N20, N9-P14 and P14-N20, were not significantly different between the two groups (Student's t test) However, the children with ESRD were significantly retarded in growth and when arm length was taken into account, a significant difference in peripheral conduction was revealed. There was no correlation with other indexes of disease severity (parathormone, aluminium, Hb, Na, K, Cl, BUN and creatinine). SEPs appear to reflect subclinical changes in peripheral conduction in sensory pathways in children with ESRD which are not correlated with other measures of disease severity.

Original languageEnglish
Pages (from-to)238-241
Number of pages4
JournalBrain and Development
Volume13
Issue number4
Publication statusPublished - 1991

Keywords

  • Children
  • End-stage renal disease
  • Somatosensory evoked potential

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

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