Somatosensory temporal discrimination in Parkinson's disease, dystonia and essential tremor: Pathophysiological and clinical implications

Antonella Conte, Gina Ferrazzano, Daniele Belvisi, Nicoletta Manzo, Emanuele Battista, Pietro Li Voti, Andrea Nardella, Giovanni Fabbrini, Alfredo Berardelli

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To investigate whether changes in the somatosensory temporal discrimination threshold (STDT) in Parkinson's disease (PD) and dystonia reflect the involvement of specific neural structures or mechanisms related to tremor, and whether the STDT can discriminate patients with PD, dystonia or essential tremor (ET).

METHODS: We tested STDT in 223 patients with PD, dystonia and ET and compared STDT values in patients with PD and dystonia with tremor with those of PD and CD without tremor. Data were compared with those of age-matched healthy subjects.

RESULTS: STDT values were high in patients with dystonia and PD but normal in ET. In PD, STDT values were similar in patients with resting or postural/action tremor and in those without tremor. In dystonia, STDT values were higher in patients with tremor than in those without tremor. The ROC curve showed that STDT discriminates tremor in dystonia from ET.

CONCLUSIONS: In PD, STDT changes likely reflect basal ganglia abnormalities and are unrelated to tremor mechanisms. In dystonia, the primary somatosensory cortex and cerebellum play an additional role.

SIGNIFICANCE: STDT provides information on the pathophysiological mechanisms of patients with movement disorders and may be used to differentiate patients with dystonia and tremor from those with tremor due to ET.

Original languageEnglish
Pages (from-to)1849-1853
Number of pages5
JournalClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Volume129
Issue number9
DOIs
Publication statusPublished - Sep 2018

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Essential Tremor
Dystonia
Tremor
Parkinson Disease
Somatosensory Cortex
Movement Disorders
Basal Ganglia
ROC Curve
Cerebellum
Healthy Volunteers

Cite this

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title = "Somatosensory temporal discrimination in Parkinson's disease, dystonia and essential tremor: Pathophysiological and clinical implications",
abstract = "OBJECTIVE: To investigate whether changes in the somatosensory temporal discrimination threshold (STDT) in Parkinson's disease (PD) and dystonia reflect the involvement of specific neural structures or mechanisms related to tremor, and whether the STDT can discriminate patients with PD, dystonia or essential tremor (ET).METHODS: We tested STDT in 223 patients with PD, dystonia and ET and compared STDT values in patients with PD and dystonia with tremor with those of PD and CD without tremor. Data were compared with those of age-matched healthy subjects.RESULTS: STDT values were high in patients with dystonia and PD but normal in ET. In PD, STDT values were similar in patients with resting or postural/action tremor and in those without tremor. In dystonia, STDT values were higher in patients with tremor than in those without tremor. The ROC curve showed that STDT discriminates tremor in dystonia from ET.CONCLUSIONS: In PD, STDT changes likely reflect basal ganglia abnormalities and are unrelated to tremor mechanisms. In dystonia, the primary somatosensory cortex and cerebellum play an additional role.SIGNIFICANCE: STDT provides information on the pathophysiological mechanisms of patients with movement disorders and may be used to differentiate patients with dystonia and tremor from those with tremor due to ET.",
author = "Antonella Conte and Gina Ferrazzano and Daniele Belvisi and Nicoletta Manzo and Emanuele Battista and {Li Voti}, Pietro and Andrea Nardella and Giovanni Fabbrini and Alfredo Berardelli",
note = "Copyright {\circledC} 2018 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.",
year = "2018",
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language = "English",
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TY - JOUR

T1 - Somatosensory temporal discrimination in Parkinson's disease, dystonia and essential tremor

T2 - Pathophysiological and clinical implications

AU - Conte, Antonella

AU - Ferrazzano, Gina

AU - Belvisi, Daniele

AU - Manzo, Nicoletta

AU - Battista, Emanuele

AU - Li Voti, Pietro

AU - Nardella, Andrea

AU - Fabbrini, Giovanni

AU - Berardelli, Alfredo

N1 - Copyright © 2018 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

PY - 2018/9

Y1 - 2018/9

N2 - OBJECTIVE: To investigate whether changes in the somatosensory temporal discrimination threshold (STDT) in Parkinson's disease (PD) and dystonia reflect the involvement of specific neural structures or mechanisms related to tremor, and whether the STDT can discriminate patients with PD, dystonia or essential tremor (ET).METHODS: We tested STDT in 223 patients with PD, dystonia and ET and compared STDT values in patients with PD and dystonia with tremor with those of PD and CD without tremor. Data were compared with those of age-matched healthy subjects.RESULTS: STDT values were high in patients with dystonia and PD but normal in ET. In PD, STDT values were similar in patients with resting or postural/action tremor and in those without tremor. In dystonia, STDT values were higher in patients with tremor than in those without tremor. The ROC curve showed that STDT discriminates tremor in dystonia from ET.CONCLUSIONS: In PD, STDT changes likely reflect basal ganglia abnormalities and are unrelated to tremor mechanisms. In dystonia, the primary somatosensory cortex and cerebellum play an additional role.SIGNIFICANCE: STDT provides information on the pathophysiological mechanisms of patients with movement disorders and may be used to differentiate patients with dystonia and tremor from those with tremor due to ET.

AB - OBJECTIVE: To investigate whether changes in the somatosensory temporal discrimination threshold (STDT) in Parkinson's disease (PD) and dystonia reflect the involvement of specific neural structures or mechanisms related to tremor, and whether the STDT can discriminate patients with PD, dystonia or essential tremor (ET).METHODS: We tested STDT in 223 patients with PD, dystonia and ET and compared STDT values in patients with PD and dystonia with tremor with those of PD and CD without tremor. Data were compared with those of age-matched healthy subjects.RESULTS: STDT values were high in patients with dystonia and PD but normal in ET. In PD, STDT values were similar in patients with resting or postural/action tremor and in those without tremor. In dystonia, STDT values were higher in patients with tremor than in those without tremor. The ROC curve showed that STDT discriminates tremor in dystonia from ET.CONCLUSIONS: In PD, STDT changes likely reflect basal ganglia abnormalities and are unrelated to tremor mechanisms. In dystonia, the primary somatosensory cortex and cerebellum play an additional role.SIGNIFICANCE: STDT provides information on the pathophysiological mechanisms of patients with movement disorders and may be used to differentiate patients with dystonia and tremor from those with tremor due to ET.

U2 - 10.1016/j.clinph.2018.05.024

DO - 10.1016/j.clinph.2018.05.024

M3 - Article

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