Somatosensory temporal discrimination tested in patients receiving botulinum toxin injection for cervical dystonia

Alessandra Scontrini, Antonella Conte, Giovanni Fabbrini, Carlo Colosimo, Flavio Di Stasio, Gina Ferrazzano, Alfredo Berardelli

Research output: Contribution to journalArticlepeer-review

Abstract

We designed this study to find out more about the relationship between the sensory effects of Botulinum toxin type A (BTX) and the clinical benefits of BTX therapy in patients with cervical dystonia (CD). In 24 patients with CD, we tested sensory temporal discrimination (STD) in the affected and two unaffected body regions (neck, hand, and eye) before and 1 month after BTX injection. In 8 out of the 24 patients with CD, STDT values were tested bilaterally in the three body regions before, 1 and 2 months after BTX injection. As expected, STD testing disclosed altered STD threshold values in all three body regions tested (affected and unaffected by dystonic spasms) in patients with CD. STD threshold values remained unchanged at all time points of the follow-up in all CD patients. The lack of BTX-induced effects on STD thresholds suggests that STD recruits neural structures uninvolved in muscle spindle afferent activation.

Original languageEnglish
Pages (from-to)742-746
Number of pages5
JournalMovement Disorders
Volume26
Issue number4
DOIs
Publication statusPublished - Mar 2011

Keywords

  • Botulinum toxin
  • Cervical dystonia
  • Somatosensory temporal discrimination

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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