Somatosensory temporal discrimination threshold is increased in patients with cerebellar atrophy

Fiore Manganelli, Raffaele Dubbioso, Chiara Pisciotta, Antonella Antenora, Maria Nolano, Giuseppe De Michele, Alessandro Filla, Alfredo Berardelli, Lucio Santoro

Research output: Contribution to journalArticle

Abstract

Processing of time in the millisecond range seems to depend on cerebellar function and it can be assessed by using the somatosensory temporal discrimination threshold testing. No studies have yet investigated this temporal discrimination task in patients with cerebellar atrophy. Eleven patients with degenerative cerebellar ataxia and 11 controls underwent somatosensory temporal discrimination threshold evaluation. The degree of cerebellar dysfunction was measured by the International Cooperative Ataxia Rating Scale. Somatosensory temporal discrimination threshold was higher in patients compared to controls for each stimulated site (hand, neck, and eye). Age, disease duration, and International Cooperative Ataxia Rating Scale scores were not correlated to somatosensory temporal discrimination threshold. Somatosensory temporal discrimination threshold is abnormal in patients with cerebellar atrophy. These findings suggest that the cerebellum plays a role in modulating the somatosensory temporal discrimination threshold and confirm the role of cerebellum in the processing of time in the millisecond range.

Original languageEnglish
Pages (from-to)456-459
Number of pages4
JournalCerebellum
Volume12
Issue number4
DOIs
Publication statusPublished - Aug 2013

    Fingerprint

Keywords

  • Cerebellar ataxia
  • Cerebellar atrophy
  • Electrical stimulation
  • STDT

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Manganelli, F., Dubbioso, R., Pisciotta, C., Antenora, A., Nolano, M., De Michele, G., Filla, A., Berardelli, A., & Santoro, L. (2013). Somatosensory temporal discrimination threshold is increased in patients with cerebellar atrophy. Cerebellum, 12(4), 456-459. https://doi.org/10.1007/s12311-012-0435-x