Somatostatin analogs in the treatment of neuroendocrine tumors: Current and emerging aspects

Gherardo Mazziotti, Alessandra Mosca, Stefano Frara, Giovanni Vitale, Andrea Giustina

Research output: Contribution to journalReview article

Abstract

Introduction: Neuroendocrine tumors (NETs) harbor somatostatin receptors and there is a strong rationale for using somatostatin analogs (SSAs) for treatment of NETs. Areas covered: This article discusses i) pharmacology of somatostatin and its analogs; ii) antisecretory and anti-proliferative effects of SSAs in NETs; iii) efficacy and safety of emerging therapeutic regimens with first generation SSAs administered at either high doses or in combination with antineoplastic drugs; iv) efficacy and safety of pasireotide and chimeric molecules; v) efficacy of radionuclide therapy of NETs using SSAs. Expert opinion: SSAs are the first-line medical therapy for functioning and non-functioning welldifferentiated NETs. In patients not responder to first generation SSAs, the increase of drug dose over the conventional regimens, the combination of SSAs with other biotherapies or molecular targeted therapies, the switch to pasireotide or the use of SSAs in radionuclide therapy may improve the therapeutic success.

Original languageEnglish
Pages (from-to)1679-1689
Number of pages11
JournalExpert Opinion on Pharmacotherapy
Volume18
Issue number16
DOIs
Publication statusPublished - Jan 1 2017

Keywords

  • Lanreotide
  • Neuroendocrine tumors
  • Octreotide
  • Pasireotide
  • Somatostatin analogs

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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