Somatostatin analogues in functioning gastroenteropancreatic neuroendocrine tumours: Literature review, clinical recommendations and schedules

Sara Massironi, Dario Conte, Roberta Elisa Rossi

Research output: Contribution to journalArticlepeer-review

Abstract

Objective Neuroendocrine tumours (NETs) represent a heterogeneous group of neoplasms, which include functioning and non-functioning forms. Somatostatin analogues (SSAs) play a key role in the management of these tumours. Herein, we aimed at reviewing the current evidence about the role of SSAs in the treatment of gastro-entero-pancreatic (GEP)-NETs. Material and methods An extensive bibliographical search was performed in PubMed using the following keywords: gastro-entero-pancreatic neuroendocrine tumours, somatostatin analogues, octreotide, lanreotide, in order to identify all the pertinent English-written articles published between 1990 and 2015. Results SSAs have shown to help the symptomatic and biochemical improvement of patients with NETs and to exhibit a good safety profile. Recent studies have also reported a role for SSAs in tumour growth control, although the results are less impressive and the underlying mechanisms are not fully understood. Conclusions SSAs are well known as a symptomatic and, to lesser extent, anti-proliferative treatment in GEP-NETs. However, some issues, including optimal dosage, benefits and adverse events of combination with other molecules, and the role of new analogues, remain to be elucidated in further randomised studies.

Original languageEnglish
Pages (from-to)513-523
Number of pages11
JournalScandinavian Journal of Gastroenterology
Volume51
Issue number5
DOIs
Publication statusPublished - May 3 2016

Keywords

  • Gastro-entero-pancreatic neuroendocrine tumours
  • lanreotide
  • octreotide
  • somatostatin analogues

ASJC Scopus subject areas

  • Gastroenterology

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