Somatostatin infusion withdrawal: Studies in normal children and in children with growth hormone deficiency

Marco Cappa, Antonello E. Rigamonti, Carla Bizzarri, Ottavia Porzio, Patrizia Civolani, Silvano G. Cella, Sandro Loche, Eugenio E. Müller

Research output: Contribution to journalArticlepeer-review

Abstract

Withdrawal of a somatostatin infusion (SSIW) is followed by a rebound rise of GH in both animals and normal adult men, a phenomenon likely mediated by endogenous GHRH function. In the present study, we have evaluated the GH response to SSIW in a group of 28 prepubertal children (18 boys and 10 girls; aged 3.7-11.1 yr). Six children had GH deficiency [GHD; GH responses to pyridostigmine (PD)+GHRH and to clonidine 7 μg/L, respectively; mean integrated nighttime GH concentrations

Original languageEnglish
Pages (from-to)4426-4430
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume84
Issue number12
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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