TY - JOUR
T1 - Somatostatin infusion withdrawal
T2 - Studies in normal children and in children with growth hormone deficiency
AU - Cappa, Marco
AU - Rigamonti, Antonello E.
AU - Bizzarri, Carla
AU - Porzio, Ottavia
AU - Civolani, Patrizia
AU - Cella, Silvano G.
AU - Loche, Sandro
AU - Müller, Eugenio E.
PY - 1999
Y1 - 1999
N2 - Withdrawal of a somatostatin infusion (SSIW) is followed by a rebound rise of GH in both animals and normal adult men, a phenomenon likely mediated by endogenous GHRH function. In the present study, we have evaluated the GH response to SSIW in a group of 28 prepubertal children (18 boys and 10 girls; aged 3.7-11.1 yr). Six children had GH deficiency [GHD; GH responses to pyridostigmine (PD)+GHRH and to clonidine 7 μg/L, respectively; mean integrated nighttime GH concentrations
AB - Withdrawal of a somatostatin infusion (SSIW) is followed by a rebound rise of GH in both animals and normal adult men, a phenomenon likely mediated by endogenous GHRH function. In the present study, we have evaluated the GH response to SSIW in a group of 28 prepubertal children (18 boys and 10 girls; aged 3.7-11.1 yr). Six children had GH deficiency [GHD; GH responses to pyridostigmine (PD)+GHRH and to clonidine 7 μg/L, respectively; mean integrated nighttime GH concentrations
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M3 - Article
C2 - 10599697
AN - SCOPUS:0033304877
VL - 84
SP - 4426
EP - 4430
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 12
ER -