Somatostatin Receptor PET/CT Imaging for the Detection and Staging of Pancreatic NET: A Systematic Review and Meta-Analysis

Matteo Bauckneht, Domenico Albano, Salvatore Annunziata, Giulia Santo, Priscilla Guglielmo, Viviana Frantellizzi, Alessia Branca, Cristina Ferrari, Antonio Vento, Alessia Mirabile, Anna Giulia Nappi, Laura Evangelista, Pierpaolo Alongi, Riccardo Laudicella

Research output: Contribution to journalReview articlepeer-review

Abstract

We investigated the diagnostic performance of Somatostatin Receptor Positron Emission Tomography/Computed Tomography (SSR-PET/CT) for the detection of primary lesion and initial staging of pancreatic neuroendocrine tumors (pNETs). A comprehensive literature search up to January 2020 was performed selecting studies in presence of: sample size ≥10 patients; index test (i.e., 68Ga-DOTATOC or 68Ga-DOTANOC or 68Ga-DOTATATE PET/CT); and outcomes (i.e., detection rate (DR), true positive, true negative, false positive, and false-negative). The methodological quality was evaluated with QUADAS-2. Pooled DR and pooled sensitivity and specificity for the identification of the primary tumor were assessed by a patient-based and a lesion-based analysis. Thirty-eight studies were selected for the qualitative analysis, while 18 papers were included in the meta-analysis. The number of pNET patients ranged from 10 to 142, for a total of 1143 subjects. At patient-based analysis, the pooled sensitivity and specificity for the assessment of primary pNET were 79.6% (95% confidence interval (95%CI): 71–87%) and 95% (95%CI: 75–100%) with a heterogeneity of 59.6% and 51.5%, respectively. Pooled DR for the primary lesion was 81% (95%CI: 65–90%) and 92% (95%CI: 80–97%), respectively, at patient-based and lesion-based analysis. In conclusion, SSR-PET/CT has high DR and diagnostic performances for primary lesion and initial staging of pNETs.

Original languageEnglish
Article number598
JournalDiagnostics
Volume10
Issue number8
DOIs
Publication statusPublished - Aug 2020

Keywords

  • Neuroendocrine tumors
  • Pancreas
  • Positron emission tomography
  • Somatostatin receptor analogs

ASJC Scopus subject areas

  • Clinical Biochemistry

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