TY - JOUR
T1 - Somatostatin receptor tissue distribution in lung neuroendocrine tumours
T2 - A clinicopathologic and immunohistochemical study of 218 'clinically aggressive' cases
AU - Righi, L.
AU - Volante, M.
AU - Tavaglione, V.
AU - Billè, A.
AU - Daniele, L.
AU - Angusti, T.
AU - Inzani, F.
AU - Pelosi, G.
AU - Rindi, G.
AU - Papotti, M.
PY - 2009/9/16
Y1 - 2009/9/16
N2 - Background: The management of pulmonary neuroendocrine tumours (NETs), with special reference to clinically aggressive carcinoids and large-cell neuroendocrine carcinomas (LCNECs), is poorly standardised and data about somatostatin receptor (SSTR) expression or therapeutic guidelines for somatostatin analogue administration are still debated. Materials and methods: A series of 218 lung NETs [24 metastatic typical carcinoids (TCs), 73 atypical carcinoids (ACs), 60 LCNECs and 61 surgically resected small-cell lung carcinomas] were investigated for SSTR types 2A and 3 tissue distribution using immunohistochemistry, in correlation with clinicopathologic parameters, outcome, scintigraphy and treatment. Results: SSTRs were heterogeneously distributed with a significant progressive decrease from low- to high-grade forms. SSTR type 2A was strikingly overexpressed in metastatic TCs as compared with ACs and clinically benign TCs. SSTR tissue immunolocalization correlated with octreotide scintigraphy in 20 of 28 cases. Conclusion: The immunohistochemical determination of SSTRs, with special reference to low-grade/intermediate-grade tumours, may assist the clinical approach with somatostatin analogue-based diagnostic and therapeutic procedures in clinically aggressive pulmonary NETs.
AB - Background: The management of pulmonary neuroendocrine tumours (NETs), with special reference to clinically aggressive carcinoids and large-cell neuroendocrine carcinomas (LCNECs), is poorly standardised and data about somatostatin receptor (SSTR) expression or therapeutic guidelines for somatostatin analogue administration are still debated. Materials and methods: A series of 218 lung NETs [24 metastatic typical carcinoids (TCs), 73 atypical carcinoids (ACs), 60 LCNECs and 61 surgically resected small-cell lung carcinomas] were investigated for SSTR types 2A and 3 tissue distribution using immunohistochemistry, in correlation with clinicopathologic parameters, outcome, scintigraphy and treatment. Results: SSTRs were heterogeneously distributed with a significant progressive decrease from low- to high-grade forms. SSTR type 2A was strikingly overexpressed in metastatic TCs as compared with ACs and clinically benign TCs. SSTR tissue immunolocalization correlated with octreotide scintigraphy in 20 of 28 cases. Conclusion: The immunohistochemical determination of SSTRs, with special reference to low-grade/intermediate-grade tumours, may assist the clinical approach with somatostatin analogue-based diagnostic and therapeutic procedures in clinically aggressive pulmonary NETs.
KW - Carcinoid
KW - Immunohistochemistry
KW - Lung
KW - Neuroendocrine tumours
KW - Scintigraphy
KW - Somatostatin receptor
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U2 - 10.1093/annonc/mdp334
DO - 10.1093/annonc/mdp334
M3 - Article
C2 - 19759190
AN - SCOPUS:76049098419
VL - 21
SP - 548
EP - 555
JO - Annals of Oncology
JF - Annals of Oncology
SN - 0923-7534
IS - 3
M1 - mdp334
ER -