Somatostatin receptor type 2A immunohistochemistry in neuroendocrine tumors: A proposal of scoring system correlated with somatostatin receptor scintigraphy

Marco Volante, Maria Pia Brizzi, Antongiulio Faggiano, Stefano La Rosa, Ida Rapa, Anna Ferrero, Gelsomina Mansueto, Luisella Righi, Silvana Garancini, Carlo Capella, Gaetano De Rosa, Luigi Dogliotti, Annamaria Colao, Mauro Papotti

Research output: Contribution to journalArticlepeer-review

Abstract

Typing somatostatin receptor expression in neuroendocrine tumors is of relevance to target somatostatin analogue-based diagnostic approach and treatment. The expanding use of immunohistochemistry to detect somatostatin receptors is to date not paralleled by an accurate methodological setting and standardized interpretation of the results. A multicentric study was designed to compare somatostatin receptor immunohistochemical expression with in vivo scintigraphic data and verify its usefulness in the clinical management of neuroendocrine tumors. After methodological setting by testing different somatostatin receptor antibodies, 107 cases of neuroendocrine tumors with available somatostatin receptor scintigraphy data and pathological material were retrospectively analyzed for somatostatin receptor types 2A, 3 and 5 immunohistochemical expression, and compared with scintigraphic images and, whenever available, with the clinical response to somatostatin analogue treatment. Restricting 'positive cases' to the presence of a membrane pattern of staining, an overall somatostatin receptor type 2A immunohistochemistry/ somatostatin receptor scintigraphy agreement of 77% (χ2 test P

Original languageEnglish
Pages (from-to)1172-1182
Number of pages11
JournalModern Pathology
Volume20
Issue number11
DOIs
Publication statusPublished - Nov 2007

Keywords

  • Immunohistochemistry
  • Neuroendocrine tumors
  • Scoring system
  • Somatostatin receptor
  • Somatostatin receptor scintigraphy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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