Some applications of nanotechnologies in stem cells research

M. Belicchi, R. Cancedda, A. Cedola, F. Fiori, M. Gavina, A. Giuliani, V. S. Komlev, S. Lagomarsino, M. Mastrogiacomo, C. Renghini, F. Rustichelli, E. Sykovà, Y. Torrente

Research output: Contribution to journalArticle

Abstract

Stem cell based tissue engineering therapies involve the administration of ex vivo manipulated stem cell populations with the purpose of repairing and regenerating damaged or diseased tissue. Currently available methods of monitoring transplanted cells are quite limited. To monitor the outcomes of stem cell therapy longitudinally requires the development of non-destructive strategies that are capable of identifying the location, magnitude, and duration of cellular survival and fate. The recent development of imaging techniques offers great potential to address these critical issues by non-invasively tracking the fate of the transplanted cells. This review offers a focused presentation of some examples of the use of imaging techniques connected to the nanotechnological world in research areas related to stem cells. In particular investigations will be considered concerning tissue-engineered bone, treatment of intervertebral disc degeneration, treatment by human stem cells of muscular dystrophy of Duchenne in small animal models and the repair of spinal cord injuries.

Original languageEnglish
Pages (from-to)139-147
Number of pages9
JournalMaterials Science and Engineering B: Solid-State Materials for Advanced Technology
Volume165
Issue number3
DOIs
Publication statusPublished - Dec 15 2009

Keywords

  • Imaging techniques
  • Nanoparticles
  • Stem cells
  • Tissue engineering

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering
  • Mechanics of Materials

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