Some aspects of the effect of nicotine on plasma FFA and tissue triglycerides

A. Bizzi, M. T. Tacconi, A. Medea, S. Garattini

Research output: Contribution to journalArticlepeer-review

Abstract

Nicotine given subcutaneously to rats raised the levels of plasma free fatty acids (FFA) and blood glucose, the content of FFA and glycerol in adipose tissue also being increased. The basal lipolysis of adipose tissue obtained from nicotine-treated rats was increased, while the lipolytic effects of norepinephrine or theophylline remained unchanged or were slightly diminished. The rise in plasma FFA was inhibited by the administration of 5-carboxy-3-methyl-pyrazole, an antilipolytic agent, or of a β-adrenergic blocker. Nicotine failed to raise plasma FFA in previously adrenalectomized rats. However, this effect was restored by the administration of corticosterone. No elevation of lipid content in the liver and heart was observed after single or repeated treatment.

Original languageEnglish
Pages (from-to)216-224
Number of pages9
JournalPharmacology
Volume7
Issue number4
DOIs
Publication statusPublished - 1972

Keywords

  • FFA
  • Glucorticoids
  • Lipolysis
  • Nicotine
  • Triglycerides

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Some aspects of the effect of nicotine on plasma FFA and tissue triglycerides'. Together they form a unique fingerprint.

Cite this