Alcuni casi di severa ipofosfatemia in Terapia Intensiva

Translated title of the contribution: Some cases of severe hypophosphatemia in intensive care

M. Pezza, C. Iermano, L. Ughi, F. Aloj, M. Giurbino

Research output: Contribution to journalArticlepeer-review


In this study we show some cases of critically ill patients with metabolic disorders due to severe hypophosphatemia that causes depletion of intracellular ATP and a decrease in erythrocyte levels of 2.3 DPG with the result of an increased affinity of O2 for hemoglobin and a reduced release of O2 to tissues. The change in tissue oxygenation causes a metabolic shift towards anaerobiosis that leads to lactic acidosis. The fall in extracellular fluid bicarbonate concentrations testifies the acute activation of the HCO3 - buffer system in order to correct the state of acidosis. In Intensive Care a condition of 'severe hypophosphatemia' can be suspected when, after the correction of acidosis with buffers, there is a fall in bicarbonate concentration not supported by clinical signs and/or laboratory findings; in this case, while waiting for the laboratory response, it can be useful to administer preparations containing phosphorus.

Translated title of the contributionSome cases of severe hypophosphatemia in intensive care
Original languageItalian
Pages (from-to)44-47
Number of pages4
JournalRivista Italiana di Nutrizione Parenterale ed Enterale
Issue number1
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Food Science
  • Anatomy
  • Critical Care and Intensive Care Medicine
  • Nutrition and Dietetics


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