Alcuni casi di severa ipofosfatemia in Terapia Intensiva

Translated title of the contribution: Some cases of severe hypophosphatemia in intensive care

M. Pezza, C. Iermano, L. Ughi, F. Aloj, M. Giurbino

Research output: Contribution to journalArticle

Abstract

In this study we show some cases of critically ill patients with metabolic disorders due to severe hypophosphatemia that causes depletion of intracellular ATP and a decrease in erythrocyte levels of 2.3 DPG with the result of an increased affinity of O2 for hemoglobin and a reduced release of O2 to tissues. The change in tissue oxygenation causes a metabolic shift towards anaerobiosis that leads to lactic acidosis. The fall in extracellular fluid bicarbonate concentrations testifies the acute activation of the HCO3 - buffer system in order to correct the state of acidosis. In Intensive Care a condition of 'severe hypophosphatemia' can be suspected when, after the correction of acidosis with buffers, there is a fall in bicarbonate concentration not supported by clinical signs and/or laboratory findings; in this case, while waiting for the laboratory response, it can be useful to administer preparations containing phosphorus.

Original languageItalian
Pages (from-to)44-47
Number of pages4
JournalRivista Italiana di Nutrizione Parenterale ed Enterale
Volume16
Issue number1
Publication statusPublished - 1998

Fingerprint

Hypophosphatemia
acidosis
Critical Care
Bicarbonates
Acidosis
Buffers
Anaerobiosis
bicarbonates
Lactic Acidosis
Extracellular Fluid
buffers
Critical Illness
Phosphorus
Hemoglobins
extracellular fluids
Adenosine Triphosphate
Erythrocytes
anaerobiosis
metabolic diseases
hemoglobin

ASJC Scopus subject areas

  • Food Science
  • Anatomy
  • Critical Care and Intensive Care Medicine
  • Nutrition and Dietetics

Cite this

Alcuni casi di severa ipofosfatemia in Terapia Intensiva. / Pezza, M.; Iermano, C.; Ughi, L.; Aloj, F.; Giurbino, M.

In: Rivista Italiana di Nutrizione Parenterale ed Enterale, Vol. 16, No. 1, 1998, p. 44-47.

Research output: Contribution to journalArticle

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