Some peculiarities of the glucoregulatory response to glucose infusion in the rat

Luigi Saccà, Franco Rengo, Gavino Perez, Giuseppe Critelli

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The glucoregulatory response to the i.v. infusion of different doses of glucose and glucose plus insulin was studied in anesthetized rats by using the primed constant infusion of glucose-2-3H. Infusion of glucose at the rate of 10 mg/kg/min induced a rise of about 100% in blood glucose, while the hepatic release of glucose showed only a small and transient decrease. A proportional increase of glycemia and glucose utilization (Rd) was observed without any appreciable change in the metabolic clearance rate (MCR) of glucose; a two-fold increase in plasma insulin was recorded at all times. In the group of rats receiving 20 mg/kg/min of glucose, changes in the above parameters were slightly greater; MCR showed a moderate increment in spite of the six-fold rise of plasma insulin. Finally, the infusion of large doses of insulin together with 20 mg/kg/min of glucose resulted in complete cessation of glucose release by the liver and in a remarkable increase of Rd and MCR. These results suggest a poor adaptability of the glucoregulatory system of the rat in response to glucose infusion as compared to other mammalian species.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalActa Diabetologica Latina
Issue number1-2
Publication statusPublished - Jan 1976


  • Glucose
  • Glucose homeostasis
  • Glucose production
  • Glucose uptake
  • Insulin
  • Metabolic clearance rate of glucose

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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