Some peculiarities of the glucoregulatory response to glucose infusion in the rat

Luigi Saccà, Franco Rengo, Gavino Perez, Giuseppe Critelli

Research output: Contribution to journalArticlepeer-review

Abstract

The glucoregulatory response to the i.v. infusion of different doses of glucose and glucose plus insulin was studied in anesthetized rats by using the primed constant infusion of glucose-2-3H. Infusion of glucose at the rate of 10 mg/kg/min induced a rise of about 100% in blood glucose, while the hepatic release of glucose showed only a small and transient decrease. A proportional increase of glycemia and glucose utilization (Rd) was observed without any appreciable change in the metabolic clearance rate (MCR) of glucose; a two-fold increase in plasma insulin was recorded at all times. In the group of rats receiving 20 mg/kg/min of glucose, changes in the above parameters were slightly greater; MCR showed a moderate increment in spite of the six-fold rise of plasma insulin. Finally, the infusion of large doses of insulin together with 20 mg/kg/min of glucose resulted in complete cessation of glucose release by the liver and in a remarkable increase of Rd and MCR. These results suggest a poor adaptability of the glucoregulatory system of the rat in response to glucose infusion as compared to other mammalian species.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalActa Diabetologica Latina
Volume13
Issue number1-2
DOIs
Publication statusPublished - Jan 1976

Keywords

  • Glucose
  • Glucose homeostasis
  • Glucose production
  • Glucose uptake
  • Insulin
  • Metabolic clearance rate of glucose

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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