Sooner or Later? Outcome Analysis of 431 Prostate Cancer Patients Treated With Postoperative or Salvage Radiotherapy

Barbara A. Jereczek-Fossa; Dario Zerini; Andrea Vavassori; Cristiana Fodor; Luigi Santoro; Antonio Minissale; Raffaella Cambria; Federica Cattani; Cristina Garibaldi; Flavia Serafini; Victor Deliu Matei; Ottavio de Cobelli; Roberto Orecchia

doi:10.1016/j.ijrobp.2008.07.057

Sooner or Later? Outcome Analysis of 431 Prostate Cancer Patients Treated With Postoperative or Salvage Radiotherapy

Barbara A. Jereczek-Fossa, Dario Zerini, Andrea Vavassori, Cristiana Fodor, Luigi Santoro, Antonio Minissale, Raffaella Cambria, Federica Cattani, Cristina Garibaldi, Flavia Serafini, Victor Deliu Matei, Ottavio de Cobelli, Roberto Orecchia

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To evaluate the outcome of postoperative radiotherapy (PORT) and salvage RT (SART) using a three-dimensional conformal two-dynamic arc (3D-ART) or 3D six-field technique in 431 prostate cancer patients. Methods and Materials: Of the 431 patients, 258 underwent PORT (started 6 (p = 0.025) and use of preoperative androgen deprivation (p = 0.002) correlated significantly with shorter failure-free survival. Multivariate analysis showed that PORT and the 3D-ART technique correlated with greater late urinary toxicity. Conclusion: PORT and early referral for SART offer better disease control after radical prostatectomy. The greater urinary toxicity occurring after PORT and 3D-ART requires further investigation to improve the therapeutic index.

Original language	English
Pages (from-to)	115-125
Number of pages	11
Journal	International Journal of Radiation Oncology Biology Physics
Volume	74
Issue number	1
DOIs	https://doi.org/10.1016/j.ijrobp.2008.07.057
Publication status	Published - May 1 2009

Keywords

Conformal radiotherapy
Dynamic arc
Postoperative radiotherapy
Prostate cancer
Salvage radiotherapy

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Radiation
Cancer Research

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Jereczek-Fossa, B. A., Zerini, D., Vavassori, A., Fodor, C., Santoro, L., Minissale, A., Cambria, R., Cattani, F., Garibaldi, C., Serafini, F., Matei, V. D., de Cobelli, O., & Orecchia, R. (2009). Sooner or Later? Outcome Analysis of 431 Prostate Cancer Patients Treated With Postoperative or Salvage Radiotherapy. International Journal of Radiation Oncology Biology Physics, 74(1), 115-125. https://doi.org/10.1016/j.ijrobp.2008.07.057

Jereczek-Fossa, BA , Zerini, D , Vavassori, A , Fodor, C, Santoro, L, Minissale, A, Cambria, R , Cattani, F , Garibaldi, C, Serafini, F, Matei, VD , de Cobelli, O & Orecchia, R 2009, 'Sooner or Later? Outcome Analysis of 431 Prostate Cancer Patients Treated With Postoperative or Salvage Radiotherapy', International Journal of Radiation Oncology Biology Physics, vol. 74, no. 1, pp. 115-125. https://doi.org/10.1016/j.ijrobp.2008.07.057

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abstract = "Purpose: To evaluate the outcome of postoperative radiotherapy (PORT) and salvage RT (SART) using a three-dimensional conformal two-dynamic arc (3D-ART) or 3D six-field technique in 431 prostate cancer patients. Methods and Materials: Of the 431 patients, 258 underwent PORT (started 6 (p = 0.025) and use of preoperative androgen deprivation (p = 0.002) correlated significantly with shorter failure-free survival. Multivariate analysis showed that PORT and the 3D-ART technique correlated with greater late urinary toxicity. Conclusion: PORT and early referral for SART offer better disease control after radical prostatectomy. The greater urinary toxicity occurring after PORT and 3D-ART requires further investigation to improve the therapeutic index.",

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author = "Jereczek-Fossa, {Barbara A.} and Dario Zerini and Andrea Vavassori and Cristiana Fodor and Luigi Santoro and Antonio Minissale and Raffaella Cambria and Federica Cattani and Cristina Garibaldi and Flavia Serafini and Matei, {Victor Deliu} and {de Cobelli}, Ottavio and Roberto Orecchia",

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AU - Jereczek-Fossa, Barbara A.

AU - Zerini, Dario

AU - Vavassori, Andrea

AU - Fodor, Cristiana

AU - Santoro, Luigi

AU - Minissale, Antonio

AU - Cambria, Raffaella

AU - Cattani, Federica

AU - Garibaldi, Cristina

AU - Serafini, Flavia

AU - Matei, Victor Deliu

AU - de Cobelli, Ottavio

AU - Orecchia, Roberto

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AB - Purpose: To evaluate the outcome of postoperative radiotherapy (PORT) and salvage RT (SART) using a three-dimensional conformal two-dynamic arc (3D-ART) or 3D six-field technique in 431 prostate cancer patients. Methods and Materials: Of the 431 patients, 258 underwent PORT (started 6 (p = 0.025) and use of preoperative androgen deprivation (p = 0.002) correlated significantly with shorter failure-free survival. Multivariate analysis showed that PORT and the 3D-ART technique correlated with greater late urinary toxicity. Conclusion: PORT and early referral for SART offer better disease control after radical prostatectomy. The greater urinary toxicity occurring after PORT and 3D-ART requires further investigation to improve the therapeutic index.

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KW - Dynamic arc

KW - Postoperative radiotherapy

KW - Prostate cancer

KW - Salvage radiotherapy

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Sooner or Later? Outcome Analysis of 431 Prostate Cancer Patients Treated With Postoperative or Salvage Radiotherapy

Abstract

Keywords

ASJC Scopus subject areas

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