Abstract
Purpose: To evaluate the outcome of postoperative radiotherapy (PORT) and salvage RT (SART) using a three-dimensional conformal two-dynamic arc (3D-ART) or 3D six-field technique in 431 prostate cancer patients. Methods and Materials: Of the 431 patients, 258 underwent PORT (started 6 (p = 0.025) and use of preoperative androgen deprivation (p = 0.002) correlated significantly with shorter failure-free survival. Multivariate analysis showed that PORT and the 3D-ART technique correlated with greater late urinary toxicity. Conclusion: PORT and early referral for SART offer better disease control after radical prostatectomy. The greater urinary toxicity occurring after PORT and 3D-ART requires further investigation to improve the therapeutic index.
Original language | English |
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Pages (from-to) | 115-125 |
Number of pages | 11 |
Journal | International Journal of Radiation Oncology Biology Physics |
Volume | 74 |
Issue number | 1 |
DOIs | |
Publication status | Published - May 1 2009 |
Keywords
- Conformal radiotherapy
- Dynamic arc
- Postoperative radiotherapy
- Prostate cancer
- Salvage radiotherapy
ASJC Scopus subject areas
- Oncology
- Radiology Nuclear Medicine and imaging
- Radiation
- Cancer Research