Sooner or Later? Outcome Analysis of 431 Prostate Cancer Patients Treated With Postoperative or Salvage Radiotherapy

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Abstract

Purpose: To evaluate the outcome of postoperative radiotherapy (PORT) and salvage RT (SART) using a three-dimensional conformal two-dynamic arc (3D-ART) or 3D six-field technique in 431 prostate cancer patients. Methods and Materials: Of the 431 patients, 258 underwent PORT (started 6 (p = 0.025) and use of preoperative androgen deprivation (p = 0.002) correlated significantly with shorter failure-free survival. Multivariate analysis showed that PORT and the 3D-ART technique correlated with greater late urinary toxicity. Conclusion: PORT and early referral for SART offer better disease control after radical prostatectomy. The greater urinary toxicity occurring after PORT and 3D-ART requires further investigation to improve the therapeutic index.

Original languageEnglish
Pages (from-to)115-125
Number of pages11
JournalInternational Journal of Radiation Oncology Biology Physics
Volume74
Issue number1
DOIs
Publication statusPublished - May 1 2009

Keywords

  • Conformal radiotherapy
  • Dynamic arc
  • Postoperative radiotherapy
  • Prostate cancer
  • Salvage radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Cancer Research

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