Sorafenib plus daily low-dose temozolomide for relapsed glioblastoma: A phase ii study

Fable Zustovich, Lorenza Landi, Giuseppe Lombardi, Camillo Porta, Luca Galli, Andrea Fontana, Domenico Amoroso, Costanza Galli, Michele Andreuccetti, Alfredo Falcone, Vittorina Zagonel

Research output: Contribution to journalArticle

Abstract

Background: Bevacizumab has provided encouraging results in relapsed glioblastoma multiforme (GBM). Pre-clinical and clinical investigations also showed that continuous low-dose temozolomide has some antiangiogenic activity. Based on this evidence, a phase II trial was designed to investigate an oral regimen of sorafenib, an oral multikinase inhibitor, and metronomic temozolomide for relapsed GBM. Patients and Methods: Forty-three patients (median age=60.0 years) naive for antiangiogenic agents received 400 mg sorafenib twice daily plus TMZ 40 mg/m2/day until disease progression. Results: Toxicity, mostly grade 1-2, was manageable. Grade 3-4 toxicities were hand-foot syndrome (n=4), hypertension (n=2), and fatigue (n=3). Five patients (12%) achieved partial response, 18 (43%) stable disease, 20 (48%) showed progression. The median time-to-progression was 3.2 months, 6-month progression-free survival was 26%, and median overall survival was 7.4 months. Conclusion: This combination of sorafenib and temozolomide was feasible and safe, showing some activity in patients with relapsed GBM.

Original languageEnglish
Pages (from-to)3487-3494
Number of pages8
JournalAnticancer Research
Volume33
Issue number8
Publication statusPublished - Aug 2013

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Keywords

  • Chemotherapy
  • Glioblastoma
  • Relapse
  • Sorafenib
  • Temozolomide

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Zustovich, F., Landi, L., Lombardi, G., Porta, C., Galli, L., Fontana, A., Amoroso, D., Galli, C., Andreuccetti, M., Falcone, A., & Zagonel, V. (2013). Sorafenib plus daily low-dose temozolomide for relapsed glioblastoma: A phase ii study. Anticancer Research, 33(8), 3487-3494.