Sorbitol malabsorption in normal volunteers and in patients with coeliac disease

G. R. Corazza, A. Strocchi, R. Rossi, D. Sirola, G. Gasbarrini

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Sorbitol is a hexahydroxy alcohol used as a sugar substitute in many dietetic foods and as a drug vehicle. Previous studies have suggested that sorbitol ingestion may be an additional cause of non-specific gastrointestinal distress. We evaluated sorbitol malabsorption in 30 healthy volunteers, seven patients with untreated coeliac disease and nine patients with coeliac disease on a gluten free diet, using a four hour H 2 breath test. After ingestion of test solutions containing sorbitol 10 and 20 g and of four sweets (6.8 g sorbitol), 90%, 100%, and 62% of healthy volunteers, respectively had significantly raised H 2 excretion, indicating malabsorption of sorbitol. Of all healthy subjects tested, 45% after 10 g, 100% after 20 g, and 50% after four sweets complained of symptoms of carbohydrate intolerance during the eight hours after sorbitol. After a 5 g dose given at concentrations of 2%, 4%, 8%, 16%, malabsorption was shown in 10%, 12%, 22%, and 43% of the healthy volunteers. Symptoms of intolerance at 5 g were experienced only at concentrations of 8% and 16%. Unlike healthy volunteers and coeliac patients on a gluten free diet, 100% of untreated coeliacs malabsorbed a 2% solution of 5 g sorbitol. These results show that malabsorption and intolerance of sorbitol may result from ingestion of doses and/or concentrations usually found in many foods and drugs; they underlie the need to consider this as a possible and hitherto underestimated cause of gastrointestinal symptoms.

Original languageEnglish
Pages (from-to)44-48
Number of pages5
JournalGut
Volume29
Issue number1
Publication statusPublished - 1988

Fingerprint

Sorbitol
Celiac Disease
Healthy Volunteers
Gluten-Free Diet
Eating
Abdomen
Sweetening Agents
Food
Breath Tests
Dietetics
Pharmaceutical Preparations
Alcohols

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Corazza, G. R., Strocchi, A., Rossi, R., Sirola, D., & Gasbarrini, G. (1988). Sorbitol malabsorption in normal volunteers and in patients with coeliac disease. Gut, 29(1), 44-48.

Sorbitol malabsorption in normal volunteers and in patients with coeliac disease. / Corazza, G. R.; Strocchi, A.; Rossi, R.; Sirola, D.; Gasbarrini, G.

In: Gut, Vol. 29, No. 1, 1988, p. 44-48.

Research output: Contribution to journalArticle

Corazza, GR, Strocchi, A, Rossi, R, Sirola, D & Gasbarrini, G 1988, 'Sorbitol malabsorption in normal volunteers and in patients with coeliac disease', Gut, vol. 29, no. 1, pp. 44-48.
Corazza GR, Strocchi A, Rossi R, Sirola D, Gasbarrini G. Sorbitol malabsorption in normal volunteers and in patients with coeliac disease. Gut. 1988;29(1):44-48.
Corazza, G. R. ; Strocchi, A. ; Rossi, R. ; Sirola, D. ; Gasbarrini, G. / Sorbitol malabsorption in normal volunteers and in patients with coeliac disease. In: Gut. 1988 ; Vol. 29, No. 1. pp. 44-48.
@article{41558ab2515b4a6da999c1816972d81f,
title = "Sorbitol malabsorption in normal volunteers and in patients with coeliac disease",
abstract = "Sorbitol is a hexahydroxy alcohol used as a sugar substitute in many dietetic foods and as a drug vehicle. Previous studies have suggested that sorbitol ingestion may be an additional cause of non-specific gastrointestinal distress. We evaluated sorbitol malabsorption in 30 healthy volunteers, seven patients with untreated coeliac disease and nine patients with coeliac disease on a gluten free diet, using a four hour H 2 breath test. After ingestion of test solutions containing sorbitol 10 and 20 g and of four sweets (6.8 g sorbitol), 90{\%}, 100{\%}, and 62{\%} of healthy volunteers, respectively had significantly raised H 2 excretion, indicating malabsorption of sorbitol. Of all healthy subjects tested, 45{\%} after 10 g, 100{\%} after 20 g, and 50{\%} after four sweets complained of symptoms of carbohydrate intolerance during the eight hours after sorbitol. After a 5 g dose given at concentrations of 2{\%}, 4{\%}, 8{\%}, 16{\%}, malabsorption was shown in 10{\%}, 12{\%}, 22{\%}, and 43{\%} of the healthy volunteers. Symptoms of intolerance at 5 g were experienced only at concentrations of 8{\%} and 16{\%}. Unlike healthy volunteers and coeliac patients on a gluten free diet, 100{\%} of untreated coeliacs malabsorbed a 2{\%} solution of 5 g sorbitol. These results show that malabsorption and intolerance of sorbitol may result from ingestion of doses and/or concentrations usually found in many foods and drugs; they underlie the need to consider this as a possible and hitherto underestimated cause of gastrointestinal symptoms.",
author = "Corazza, {G. R.} and A. Strocchi and R. Rossi and D. Sirola and G. Gasbarrini",
year = "1988",
language = "English",
volume = "29",
pages = "44--48",
journal = "Gut",
issn = "0017-5749",
publisher = "BMJ Publishing Group",
number = "1",

}

TY - JOUR

T1 - Sorbitol malabsorption in normal volunteers and in patients with coeliac disease

AU - Corazza, G. R.

AU - Strocchi, A.

AU - Rossi, R.

AU - Sirola, D.

AU - Gasbarrini, G.

PY - 1988

Y1 - 1988

N2 - Sorbitol is a hexahydroxy alcohol used as a sugar substitute in many dietetic foods and as a drug vehicle. Previous studies have suggested that sorbitol ingestion may be an additional cause of non-specific gastrointestinal distress. We evaluated sorbitol malabsorption in 30 healthy volunteers, seven patients with untreated coeliac disease and nine patients with coeliac disease on a gluten free diet, using a four hour H 2 breath test. After ingestion of test solutions containing sorbitol 10 and 20 g and of four sweets (6.8 g sorbitol), 90%, 100%, and 62% of healthy volunteers, respectively had significantly raised H 2 excretion, indicating malabsorption of sorbitol. Of all healthy subjects tested, 45% after 10 g, 100% after 20 g, and 50% after four sweets complained of symptoms of carbohydrate intolerance during the eight hours after sorbitol. After a 5 g dose given at concentrations of 2%, 4%, 8%, 16%, malabsorption was shown in 10%, 12%, 22%, and 43% of the healthy volunteers. Symptoms of intolerance at 5 g were experienced only at concentrations of 8% and 16%. Unlike healthy volunteers and coeliac patients on a gluten free diet, 100% of untreated coeliacs malabsorbed a 2% solution of 5 g sorbitol. These results show that malabsorption and intolerance of sorbitol may result from ingestion of doses and/or concentrations usually found in many foods and drugs; they underlie the need to consider this as a possible and hitherto underestimated cause of gastrointestinal symptoms.

AB - Sorbitol is a hexahydroxy alcohol used as a sugar substitute in many dietetic foods and as a drug vehicle. Previous studies have suggested that sorbitol ingestion may be an additional cause of non-specific gastrointestinal distress. We evaluated sorbitol malabsorption in 30 healthy volunteers, seven patients with untreated coeliac disease and nine patients with coeliac disease on a gluten free diet, using a four hour H 2 breath test. After ingestion of test solutions containing sorbitol 10 and 20 g and of four sweets (6.8 g sorbitol), 90%, 100%, and 62% of healthy volunteers, respectively had significantly raised H 2 excretion, indicating malabsorption of sorbitol. Of all healthy subjects tested, 45% after 10 g, 100% after 20 g, and 50% after four sweets complained of symptoms of carbohydrate intolerance during the eight hours after sorbitol. After a 5 g dose given at concentrations of 2%, 4%, 8%, 16%, malabsorption was shown in 10%, 12%, 22%, and 43% of the healthy volunteers. Symptoms of intolerance at 5 g were experienced only at concentrations of 8% and 16%. Unlike healthy volunteers and coeliac patients on a gluten free diet, 100% of untreated coeliacs malabsorbed a 2% solution of 5 g sorbitol. These results show that malabsorption and intolerance of sorbitol may result from ingestion of doses and/or concentrations usually found in many foods and drugs; they underlie the need to consider this as a possible and hitherto underestimated cause of gastrointestinal symptoms.

UR - http://www.scopus.com/inward/record.url?scp=0023846711&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023846711&partnerID=8YFLogxK

M3 - Article

VL - 29

SP - 44

EP - 48

JO - Gut

JF - Gut

SN - 0017-5749

IS - 1

ER -