Sorbitol malabsorption in normal volunteers and in patients with coeliac disease

G. R. Corazza, A. Strocchi, R. Rossi, D. Sirola, G. Gasbarrini

Research output: Contribution to journalArticle

Abstract

Sorbitol is a hexahydroxy alcohol used as a sugar substitute in many dietetic foods and as a drug vehicle. Previous studies have suggested that sorbitol ingestion may be an additional cause of non-specific gastrointestinal distress. We evaluated sorbitol malabsorption in 30 healthy volunteers, seven patients with untreated coeliac disease and nine patients with coeliac disease on a gluten free diet, using a four hour H 2 breath test. After ingestion of test solutions containing sorbitol 10 and 20 g and of four sweets (6.8 g sorbitol), 90%, 100%, and 62% of healthy volunteers, respectively had significantly raised H 2 excretion, indicating malabsorption of sorbitol. Of all healthy subjects tested, 45% after 10 g, 100% after 20 g, and 50% after four sweets complained of symptoms of carbohydrate intolerance during the eight hours after sorbitol. After a 5 g dose given at concentrations of 2%, 4%, 8%, 16%, malabsorption was shown in 10%, 12%, 22%, and 43% of the healthy volunteers. Symptoms of intolerance at 5 g were experienced only at concentrations of 8% and 16%. Unlike healthy volunteers and coeliac patients on a gluten free diet, 100% of untreated coeliacs malabsorbed a 2% solution of 5 g sorbitol. These results show that malabsorption and intolerance of sorbitol may result from ingestion of doses and/or concentrations usually found in many foods and drugs; they underlie the need to consider this as a possible and hitherto underestimated cause of gastrointestinal symptoms.

Original languageEnglish
Pages (from-to)44-48
Number of pages5
JournalGut
Volume29
Issue number1
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Gastroenterology

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    Corazza, G. R., Strocchi, A., Rossi, R., Sirola, D., & Gasbarrini, G. (1988). Sorbitol malabsorption in normal volunteers and in patients with coeliac disease. Gut, 29(1), 44-48.