Source model and scalp topography of pattern reversal visual evoked potentials to altitudinal stimuli suggest that infoldings of calcarine fissure are not part of VEP generators

Marco Onofrj, Tommaso Fulgente, Astrid Thomas, Goffredo Malatesta, Marco Peresson, Tiziana Locatelli, Vittorio Martinelli, Giancarlo Comi

Research output: Contribution to journalArticle

Abstract

Visual evoked potentials (VEPs) to pattern reversal vertical bar stimuli were recorded from 19 scalp, 2 zygomatic and 3 inion derivations referenced to digitally linked earlobes in 50 controls. 1, 2 and 4 cycles per degree (cpd) patterns were presented as full field (FF) stimuli, on upper and lower hemifields (UHF-LHF), upper and lower quadrants and with the occlusion of central and peripheral UHF and LHF. VEPs to octant stimuli were also recorded with 2 cpd patterns. N1, P1 and N2 components were recorded from posterior and inion derivations with FF stimuli, from posterior derivations with LHF stimuli, only from inion leads with UHF stimuli, from derivations ipsilateral to stimuli with quadrants and octants, and from midline derivations only with lower quadrants. Polarity inverted sequences (iPl-iNl-iP2) were recorded from the other scalp derivations, with similar latency and spatial frequency sensitivity as N1-P1-N2. The orientation of Equivalent Dipoles (ED) was orthogonal with surface coordinates of mesial and occipito-polar calcarine cortex, measured on Magnetic Resonance Imaging. A model of VEP generators is proposed, suggesting that the VEP sequence is elicited only in mesial and occipito-polar surfaces of calcarine cortex.

Original languageEnglish
Pages (from-to)217-231
Number of pages15
JournalBrain Topography
Volume7
Issue number3
DOIs
Publication statusPublished - Mar 1995

Keywords

  • Topographic mapping
  • Visual cortex
  • Visual evoked response
  • Visual pathways

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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