Sources for skeletal muscle repair

From satellite cells to reprogramming

Dario Sirabella, Luciana De Angelis, Libera Berghella

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Skeletal muscle regeneration is the process that ensures tissue repair after damage by injury or in degenerative diseases such as muscular dystrophy. Satellite cells, the adult skeletal muscle progenitor cells, are commonly considered to be the main cell type involved in skeletal muscle regeneration. Their mechanism of action in this process is extensively characterized. However, evidence accumulated in the last decade suggests that other cell types may participate in skeletal muscle regeneration. Although their actual contribution to muscle formation and regeneration is still not clear; if properly manipulated, these cells may become new suitable and powerful sources for cell therapy of skeletal muscle degenerative diseases. Mesoangioblasts, vessel associated stem/progenitor cells with high proliferative, migratory and myogenic potential, are very good candidates for clinical applications and are already in clinical experimentation. In addition, pluripotent stem cells are very promising sources for regeneration of most tissues, including skeletal muscle. Conditions such as muscle cachexia or aging that severely alter homeostasis may be counteracted by transplantation of donor and/or recruitment and activation of resident muscle stem/progenitor cells. Advantages and limitations of different cell therapy approaches will be discussed.

Original languageEnglish
Pages (from-to)125-136
Number of pages12
JournalJournal of Cachexia, Sarcopenia and Muscle
Volume4
Issue number2
DOIs
Publication statusPublished - 2013

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Regeneration
Skeletal Muscle
Stem Cells
Cell- and Tissue-Based Therapy
Muscle Cells
Muscles
Pluripotent Stem Cells
Cachexia
Muscular Dystrophies
Homeostasis
Transplantation
Cellular Reprogramming
Wounds and Injuries

Keywords

  • Reprogramming
  • Satellite cells
  • Skeletal muscle repair

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physiology (medical)

Cite this

Sources for skeletal muscle repair : From satellite cells to reprogramming. / Sirabella, Dario; De Angelis, Luciana; Berghella, Libera.

In: Journal of Cachexia, Sarcopenia and Muscle, Vol. 4, No. 2, 2013, p. 125-136.

Research output: Contribution to journalArticle

Sirabella, Dario ; De Angelis, Luciana ; Berghella, Libera. / Sources for skeletal muscle repair : From satellite cells to reprogramming. In: Journal of Cachexia, Sarcopenia and Muscle. 2013 ; Vol. 4, No. 2. pp. 125-136.
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