Sources of cortical rhythms change as a function of cognitive impairment in pathological aging: A multicenter study

Claudio Babiloni, Giuliano Binetti, Emanuele Cassetta, Gloria Dal Forno, Claudio Del Percio, Florinda Ferreri, Raffaele Ferri, Giovanni Frisoni, Koichi Hirata, Bartolo Lanuzza, Carlo Miniussi, Davide V. Moretti, Flavio Nobili, Guido Rodriguez, Gian Luca Romani, Serenella Salinari, Paolo M. Rossini

Research output: Contribution to journalArticle

Abstract

Objective: The present study tested the hypothesis that cortical electroencephalographic (EEG) rhythms. change across normal elderly (Nold), mild cognitive impairment (MCI), and Alzheimer's disease (AD) subjects as a function of the global cognitive level. Methods: Resting eyes-closed EEG data were recorded in 155 MCI, 193 mild AD, and 126 age-matched Nold subjects. EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), and beta 2 (20-30 Hz). EEG cortical sources were estimated by LORETA. Results: Occipital delta and alpha 1 sources in parietal, occipital, temporal, and 'limbic' areas had an intermediate magnitude in MCI subjects compared to mild AD and Nold subjects. These five EEG sources presented both linear and nonlinear (linear, exponential, logarithmic, and power) correlations with the global cognitive level (as revealed by mini mental state examination score) across all subjects. Conclusions: Cortical EEG rhythms change in pathological aging as a function of the global cognitive level. Significance: The present functional data on large populations support the 'transitional hypothesis' of a shadow zone across normality, pre-clinical stage of dementia (MCI), and AD.

Original languageEnglish
Pages (from-to)252-268
Number of pages17
JournalClinical Neurophysiology
Volume117
Issue number2
DOIs
Publication statusPublished - Feb 2006

Keywords

  • Alpha rhythm
  • Electroencephalography (EEG)
  • Low resolution brain electromagnetic tomography (LORETA)
  • Mild Alzheimer's disease (mild AD)
  • Mild cognitive impairment (MCI)

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems
  • Physiology (medical)

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