Spécificité 52 kDa et 60 kDa des anti-Ro(SS-A) dans les connectivites inclassables

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Abstract

Anti-Ro(SS-A) 52 kDa and 60 kDa specificities in undifferentiated connective tissue disease. - Objective. Autoantibodies to Ro(SS-A) may recognize two different polypeptides, of 52 kDa and 60 kDa, respectively. Methods. We used an ELISA with purified human recombinant antigens to conduct a detailed analysis of the specificities of anti-Ro(SS-A) antibodies from 170 patients with definite diagnoses (systemic lupus erythematosus [SLE], n = 55; primary Sjögren's syndrome [PSS], n = 39; systemic sclerosis, n = 9; rheumatoid arthritis [RA], n = 10) or undifferentiated connective tissue disease (UCTD, n = 57). Most of the patients with SLE or PSS had both anti-52 kDa and -60 antibodies; isolated anti-60 kDa antibodies were found in 13 % of the SLE patients and in none of the PSS patients, whereas high titers of anti-52 kDa were more common in the PSS than in the SLE patients. Results. In the UCTD patients, the anti-Ro(SS-A) profile showed no significant correlations with clinical features but was associated with the clinical outcome. Over the mean follow-up of five years, definite SLE developed in four of the five UCTD patients with isolated anti-60 kDa vs only one of the remaining 52 patients (p <0.0001); progression to PSS was seen in seven of the 34 patients with both anti-52 kDa and anti-60 kDa vs none of the remaining 23 patients (ρ = 0.03); none of the 12 patients with isolated anti-52 kDa developed a definite connective tissue disease. Conclusion. Our study suggests that analysis of anti-Ro(SS-A) specificity may provide useful information for predicting the course of UCTD.

Original languageEnglish
Pages (from-to)197-202
Number of pages6
JournalRevue du Rhumatisme (Edition Francaise)
Volume67
Issue number3
Publication statusPublished - Apr 2000

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Systemic Lupus Erythematosus
Connective Tissue Diseases
Antibodies
Systemic Scleroderma
Autoantibodies
Anti-Idiotypic Antibodies
Rheumatoid Arthritis
Enzyme-Linked Immunosorbent Assay
Antigens
Peptides

Keywords

  • Anti-Ro(SS-A) autoantibodies
  • Auto-anticorps anti-Ro(SS-A)
  • Connectivites inclassables
  • Undifferentiated connective tissue disease

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

@article{0daff9ea6e194e81be92527729734494,
title = "Sp{\'e}cificit{\'e} 52 kDa et 60 kDa des anti-Ro(SS-A) dans les connectivites inclassables",
abstract = "Anti-Ro(SS-A) 52 kDa and 60 kDa specificities in undifferentiated connective tissue disease. - Objective. Autoantibodies to Ro(SS-A) may recognize two different polypeptides, of 52 kDa and 60 kDa, respectively. Methods. We used an ELISA with purified human recombinant antigens to conduct a detailed analysis of the specificities of anti-Ro(SS-A) antibodies from 170 patients with definite diagnoses (systemic lupus erythematosus [SLE], n = 55; primary Sj{\"o}gren's syndrome [PSS], n = 39; systemic sclerosis, n = 9; rheumatoid arthritis [RA], n = 10) or undifferentiated connective tissue disease (UCTD, n = 57). Most of the patients with SLE or PSS had both anti-52 kDa and -60 antibodies; isolated anti-60 kDa antibodies were found in 13 {\%} of the SLE patients and in none of the PSS patients, whereas high titers of anti-52 kDa were more common in the PSS than in the SLE patients. Results. In the UCTD patients, the anti-Ro(SS-A) profile showed no significant correlations with clinical features but was associated with the clinical outcome. Over the mean follow-up of five years, definite SLE developed in four of the five UCTD patients with isolated anti-60 kDa vs only one of the remaining 52 patients (p <0.0001); progression to PSS was seen in seven of the 34 patients with both anti-52 kDa and anti-60 kDa vs none of the remaining 23 patients (ρ = 0.03); none of the 12 patients with isolated anti-52 kDa developed a definite connective tissue disease. Conclusion. Our study suggests that analysis of anti-Ro(SS-A) specificity may provide useful information for predicting the course of UCTD.",
keywords = "Anti-Ro(SS-A) autoantibodies, Auto-anticorps anti-Ro(SS-A), Connectivites inclassables, Undifferentiated connective tissue disease",
author = "Norma Belfiore and Silvia Rossi and Francesca Bobbio-Pallavicini and Oscar Epis and Roberto Caporali and Carlomaurizio Montecucco",
year = "2000",
month = "4",
language = "English",
volume = "67",
pages = "197--202",
journal = "Revue du Rhumatisme (English Edition)",
issn = "0035-2659",
publisher = "Elsevier Masson",
number = "3",

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TY - JOUR

T1 - Spécificité 52 kDa et 60 kDa des anti-Ro(SS-A) dans les connectivites inclassables

AU - Belfiore, Norma

AU - Rossi, Silvia

AU - Bobbio-Pallavicini, Francesca

AU - Epis, Oscar

AU - Caporali, Roberto

AU - Montecucco, Carlomaurizio

PY - 2000/4

Y1 - 2000/4

N2 - Anti-Ro(SS-A) 52 kDa and 60 kDa specificities in undifferentiated connective tissue disease. - Objective. Autoantibodies to Ro(SS-A) may recognize two different polypeptides, of 52 kDa and 60 kDa, respectively. Methods. We used an ELISA with purified human recombinant antigens to conduct a detailed analysis of the specificities of anti-Ro(SS-A) antibodies from 170 patients with definite diagnoses (systemic lupus erythematosus [SLE], n = 55; primary Sjögren's syndrome [PSS], n = 39; systemic sclerosis, n = 9; rheumatoid arthritis [RA], n = 10) or undifferentiated connective tissue disease (UCTD, n = 57). Most of the patients with SLE or PSS had both anti-52 kDa and -60 antibodies; isolated anti-60 kDa antibodies were found in 13 % of the SLE patients and in none of the PSS patients, whereas high titers of anti-52 kDa were more common in the PSS than in the SLE patients. Results. In the UCTD patients, the anti-Ro(SS-A) profile showed no significant correlations with clinical features but was associated with the clinical outcome. Over the mean follow-up of five years, definite SLE developed in four of the five UCTD patients with isolated anti-60 kDa vs only one of the remaining 52 patients (p <0.0001); progression to PSS was seen in seven of the 34 patients with both anti-52 kDa and anti-60 kDa vs none of the remaining 23 patients (ρ = 0.03); none of the 12 patients with isolated anti-52 kDa developed a definite connective tissue disease. Conclusion. Our study suggests that analysis of anti-Ro(SS-A) specificity may provide useful information for predicting the course of UCTD.

AB - Anti-Ro(SS-A) 52 kDa and 60 kDa specificities in undifferentiated connective tissue disease. - Objective. Autoantibodies to Ro(SS-A) may recognize two different polypeptides, of 52 kDa and 60 kDa, respectively. Methods. We used an ELISA with purified human recombinant antigens to conduct a detailed analysis of the specificities of anti-Ro(SS-A) antibodies from 170 patients with definite diagnoses (systemic lupus erythematosus [SLE], n = 55; primary Sjögren's syndrome [PSS], n = 39; systemic sclerosis, n = 9; rheumatoid arthritis [RA], n = 10) or undifferentiated connective tissue disease (UCTD, n = 57). Most of the patients with SLE or PSS had both anti-52 kDa and -60 antibodies; isolated anti-60 kDa antibodies were found in 13 % of the SLE patients and in none of the PSS patients, whereas high titers of anti-52 kDa were more common in the PSS than in the SLE patients. Results. In the UCTD patients, the anti-Ro(SS-A) profile showed no significant correlations with clinical features but was associated with the clinical outcome. Over the mean follow-up of five years, definite SLE developed in four of the five UCTD patients with isolated anti-60 kDa vs only one of the remaining 52 patients (p <0.0001); progression to PSS was seen in seven of the 34 patients with both anti-52 kDa and anti-60 kDa vs none of the remaining 23 patients (ρ = 0.03); none of the 12 patients with isolated anti-52 kDa developed a definite connective tissue disease. Conclusion. Our study suggests that analysis of anti-Ro(SS-A) specificity may provide useful information for predicting the course of UCTD.

KW - Anti-Ro(SS-A) autoantibodies

KW - Auto-anticorps anti-Ro(SS-A)

KW - Connectivites inclassables

KW - Undifferentiated connective tissue disease

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AN - SCOPUS:0347370341

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SN - 0035-2659

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