Abstract
Anti-Ro(SS-A) 52 kDa and 60 kDa specificities in undifferentiated connective tissue disease. - Objective. Autoantibodies to Ro(SS-A) may recognize two different polypeptides, of 52 kDa and 60 kDa, respectively. Methods. We used an ELISA with purified human recombinant antigens to conduct a detailed analysis of the specificities of anti-Ro(SS-A) antibodies from 170 patients with definite diagnoses (systemic lupus erythematosus [SLE], n = 55; primary Sjögren's syndrome [PSS], n = 39; systemic sclerosis, n = 9; rheumatoid arthritis [RA], n = 10) or undifferentiated connective tissue disease (UCTD, n = 57). Most of the patients with SLE or PSS had both anti-52 kDa and -60 antibodies; isolated anti-60 kDa antibodies were found in 13 % of the SLE patients and in none of the PSS patients, whereas high titers of anti-52 kDa were more common in the PSS than in the SLE patients. Results. In the UCTD patients, the anti-Ro(SS-A) profile showed no significant correlations with clinical features but was associated with the clinical outcome. Over the mean follow-up of five years, definite SLE developed in four of the five UCTD patients with isolated anti-60 kDa vs only one of the remaining 52 patients (p <0.0001); progression to PSS was seen in seven of the 34 patients with both anti-52 kDa and anti-60 kDa vs none of the remaining 23 patients (ρ = 0.03); none of the 12 patients with isolated anti-52 kDa developed a definite connective tissue disease. Conclusion. Our study suggests that analysis of anti-Ro(SS-A) specificity may provide useful information for predicting the course of UCTD.
| Original language | English |
|---|---|
| Pages (from-to) | 197-202 |
| Number of pages | 6 |
| Journal | Revue du Rhumatisme (Edition Francaise) |
| Volume | 67 |
| Issue number | 3 |
| Publication status | Published - Apr 2000 |
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Keywords
- Anti-Ro(SS-A) autoantibodies
- Auto-anticorps anti-Ro(SS-A)
- Connectivites inclassables
- Undifferentiated connective tissue disease
ASJC Scopus subject areas
- Orthopedics and Sports Medicine
Cite this
Spécificité 52 kDa et 60 kDa des anti-Ro(SS-A) dans les connectivites inclassables. / Belfiore, Norma; Rossi, Silvia; Bobbio-Pallavicini, Francesca; Epis, Oscar; Caporali, Roberto; Montecucco, Carlomaurizio.
In: Revue du Rhumatisme (Edition Francaise), Vol. 67, No. 3, 04.2000, p. 197-202.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Spécificité 52 kDa et 60 kDa des anti-Ro(SS-A) dans les connectivites inclassables
AU - Belfiore, Norma
AU - Rossi, Silvia
AU - Bobbio-Pallavicini, Francesca
AU - Epis, Oscar
AU - Caporali, Roberto
AU - Montecucco, Carlomaurizio
PY - 2000/4
Y1 - 2000/4
N2 - Anti-Ro(SS-A) 52 kDa and 60 kDa specificities in undifferentiated connective tissue disease. - Objective. Autoantibodies to Ro(SS-A) may recognize two different polypeptides, of 52 kDa and 60 kDa, respectively. Methods. We used an ELISA with purified human recombinant antigens to conduct a detailed analysis of the specificities of anti-Ro(SS-A) antibodies from 170 patients with definite diagnoses (systemic lupus erythematosus [SLE], n = 55; primary Sjögren's syndrome [PSS], n = 39; systemic sclerosis, n = 9; rheumatoid arthritis [RA], n = 10) or undifferentiated connective tissue disease (UCTD, n = 57). Most of the patients with SLE or PSS had both anti-52 kDa and -60 antibodies; isolated anti-60 kDa antibodies were found in 13 % of the SLE patients and in none of the PSS patients, whereas high titers of anti-52 kDa were more common in the PSS than in the SLE patients. Results. In the UCTD patients, the anti-Ro(SS-A) profile showed no significant correlations with clinical features but was associated with the clinical outcome. Over the mean follow-up of five years, definite SLE developed in four of the five UCTD patients with isolated anti-60 kDa vs only one of the remaining 52 patients (p <0.0001); progression to PSS was seen in seven of the 34 patients with both anti-52 kDa and anti-60 kDa vs none of the remaining 23 patients (ρ = 0.03); none of the 12 patients with isolated anti-52 kDa developed a definite connective tissue disease. Conclusion. Our study suggests that analysis of anti-Ro(SS-A) specificity may provide useful information for predicting the course of UCTD.
AB - Anti-Ro(SS-A) 52 kDa and 60 kDa specificities in undifferentiated connective tissue disease. - Objective. Autoantibodies to Ro(SS-A) may recognize two different polypeptides, of 52 kDa and 60 kDa, respectively. Methods. We used an ELISA with purified human recombinant antigens to conduct a detailed analysis of the specificities of anti-Ro(SS-A) antibodies from 170 patients with definite diagnoses (systemic lupus erythematosus [SLE], n = 55; primary Sjögren's syndrome [PSS], n = 39; systemic sclerosis, n = 9; rheumatoid arthritis [RA], n = 10) or undifferentiated connective tissue disease (UCTD, n = 57). Most of the patients with SLE or PSS had both anti-52 kDa and -60 antibodies; isolated anti-60 kDa antibodies were found in 13 % of the SLE patients and in none of the PSS patients, whereas high titers of anti-52 kDa were more common in the PSS than in the SLE patients. Results. In the UCTD patients, the anti-Ro(SS-A) profile showed no significant correlations with clinical features but was associated with the clinical outcome. Over the mean follow-up of five years, definite SLE developed in four of the five UCTD patients with isolated anti-60 kDa vs only one of the remaining 52 patients (p <0.0001); progression to PSS was seen in seven of the 34 patients with both anti-52 kDa and anti-60 kDa vs none of the remaining 23 patients (ρ = 0.03); none of the 12 patients with isolated anti-52 kDa developed a definite connective tissue disease. Conclusion. Our study suggests that analysis of anti-Ro(SS-A) specificity may provide useful information for predicting the course of UCTD.
KW - Anti-Ro(SS-A) autoantibodies
KW - Auto-anticorps anti-Ro(SS-A)
KW - Connectivites inclassables
KW - Undifferentiated connective tissue disease
UR - http://www.scopus.com/inward/record.url?scp=0347370341&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0347370341&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0347370341
VL - 67
SP - 197
EP - 202
JO - Revue du Rhumatisme (English Edition)
JF - Revue du Rhumatisme (English Edition)
SN - 0035-2659
IS - 3
ER -