Spasmodic Dysphonia in Multiple Sclerosis Treatment With Botulin Toxin A: A Pilot Study

Arianna Di Stadio; Evanthia Bernitsas; Domenico Antonio Restivo; Enrico Alfonsi; Rosario Marchese-Ragona

doi:10.1016/j.jvoice.2018.01.002

Spasmodic Dysphonia in Multiple Sclerosis Treatment With Botulin Toxin A: A Pilot Study

Arianna Di Stadio, Evanthia Bernitsas, Domenico Antonio Restivo, Enrico Alfonsi, Rosario Marchese-Ragona

Research output: Contribution to journal › Article

Abstract

Objectives: This study aims to evaluate the effect of botulin toxin A in patients with multiple sclerosis (MS) affected by spasmodic dysphonia (SD) and to show the safety and effectiveness of this treatment in long-term observation. Materials and methods: This is a pilot study on three relapsing-remitting MS patients with SD and their response to botulin toxin A. Results: None of the patients reported dysphagia or other adverse events. Significant improvement was observed in terms of both voice quality and laryngostroboscopy results. The treatment effect was durable for 6–8 months. Conclusions: Botulin toxin A is a safe treatment that can be successfully used to treat SD in patients with MS. Larger studies are necessary to confirm our results.

Original language	English
Journal	Journal of Voice
DOIs	https://doi.org/10.1016/j.jvoice.2018.01.002
Publication status	Accepted/In press - Jan 1 2018

Keywords

Botulin toxin A
Dysphonia
Multiple sclerosis
Spasmodic dysphonia
Treatment

ASJC Scopus subject areas

Otorhinolaryngology
Speech and Hearing
LPN and LVN

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Di Stadio, A., Bernitsas, E., Restivo, D. A., Alfonsi, E., & Marchese-Ragona, R. (Accepted/In press). Spasmodic Dysphonia in Multiple Sclerosis Treatment With Botulin Toxin A: A Pilot Study. Journal of Voice. https://doi.org/10.1016/j.jvoice.2018.01.002

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abstract = "Objectives: This study aims to evaluate the effect of botulin toxin A in patients with multiple sclerosis (MS) affected by spasmodic dysphonia (SD) and to show the safety and effectiveness of this treatment in long-term observation. Materials and methods: This is a pilot study on three relapsing-remitting MS patients with SD and their response to botulin toxin A. Results: None of the patients reported dysphagia or other adverse events. Significant improvement was observed in terms of both voice quality and laryngostroboscopy results. The treatment effect was durable for 6–8 months. Conclusions: Botulin toxin A is a safe treatment that can be successfully used to treat SD in patients with MS. Larger studies are necessary to confirm our results.",

keywords = "Botulin toxin A, Dysphonia, Multiple sclerosis, Spasmodic dysphonia, Treatment",

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AU - Di Stadio, Arianna

AU - Bernitsas, Evanthia

AU - Restivo, Domenico Antonio

AU - Alfonsi, Enrico

AU - Marchese-Ragona, Rosario

PY - 2018/1/1

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N2 - Objectives: This study aims to evaluate the effect of botulin toxin A in patients with multiple sclerosis (MS) affected by spasmodic dysphonia (SD) and to show the safety and effectiveness of this treatment in long-term observation. Materials and methods: This is a pilot study on three relapsing-remitting MS patients with SD and their response to botulin toxin A. Results: None of the patients reported dysphagia or other adverse events. Significant improvement was observed in terms of both voice quality and laryngostroboscopy results. The treatment effect was durable for 6–8 months. Conclusions: Botulin toxin A is a safe treatment that can be successfully used to treat SD in patients with MS. Larger studies are necessary to confirm our results.

AB - Objectives: This study aims to evaluate the effect of botulin toxin A in patients with multiple sclerosis (MS) affected by spasmodic dysphonia (SD) and to show the safety and effectiveness of this treatment in long-term observation. Materials and methods: This is a pilot study on three relapsing-remitting MS patients with SD and their response to botulin toxin A. Results: None of the patients reported dysphagia or other adverse events. Significant improvement was observed in terms of both voice quality and laryngostroboscopy results. The treatment effect was durable for 6–8 months. Conclusions: Botulin toxin A is a safe treatment that can be successfully used to treat SD in patients with MS. Larger studies are necessary to confirm our results.

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KW - Spasmodic dysphonia

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