Spasmodic Dysphonia in Multiple Sclerosis Treatment With Botulin Toxin A: A Pilot Study

Arianna Di Stadio, Evanthia Bernitsas, Domenico Antonio Restivo, Enrico Alfonsi, Rosario Marchese-Ragona

Research output: Contribution to journalArticlepeer-review


Objectives: This study aims to evaluate the effect of botulin toxin A in patients with multiple sclerosis (MS) affected by spasmodic dysphonia (SD) and to show the safety and effectiveness of this treatment in long-term observation. Materials and methods: This is a pilot study on three relapsing-remitting MS patients with SD and their response to botulin toxin A. Results: None of the patients reported dysphagia or other adverse events. Significant improvement was observed in terms of both voice quality and laryngostroboscopy results. The treatment effect was durable for 6–8 months. Conclusions: Botulin toxin A is a safe treatment that can be successfully used to treat SD in patients with MS. Larger studies are necessary to confirm our results.

Original languageEnglish
JournalJournal of Voice
Publication statusAccepted/In press - Jan 1 2018


  • Botulin toxin A
  • Dysphonia
  • Multiple sclerosis
  • Spasmodic dysphonia
  • Treatment

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Speech and Hearing
  • LPN and LVN


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