Spasticity as an ictal pattern due to excitotoxic upper motor neuron damage

C. Liguori, M. G. Marciani, M. Albanese, R. Massa, F. Izzi, F. Placidi, N. B. Mercuri, A. Romigi

Research output: Contribution to journalArticlepeer-review


We describe the case of a man who presented with spasticity and aphasia related to continuous electroencephalographic epileptic activity in the left frontal-temporal regions. Magnetic resonance imaging (MRI) documented in diffusion-weighted images (DWI) two areas of restricted diffusion in the left frontal and temporal cortex. After starting treatment with levetiracetam 3000. mg/day there was progressive recovery of the clinical picture as well as the gradual disappearance of the electroencephalographic seizure activity and the vanishing of areas of restricted diffusion in brain MRI. Based on the clinical, EEG and MRI data, we hypothesized that both aphasia and spasticity represented ictal signs. To our knowledge, this is the first case report of ictal spasticity.

Original languageEnglish
Pages (from-to)397-400
Number of pages4
JournalEpilepsy and Behavior
Issue number3
Publication statusPublished - Nov 2012


  • Aphasia MRI DWI
  • EEG
  • Ictal spasticity
  • Status epilepticus

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology


Dive into the research topics of 'Spasticity as an ictal pattern due to excitotoxic upper motor neuron damage'. Together they form a unique fingerprint.

Cite this