Spasticity as an ictal pattern due to excitotoxic upper motor neuron damage

C. Liguori, M. G. Marciani, M. Albanese, R. Massa, F. Izzi, F. Placidi, N. B. Mercuri, A. Romigi

Research output: Contribution to journalArticle

Abstract

We describe the case of a man who presented with spasticity and aphasia related to continuous electroencephalographic epileptic activity in the left frontal-temporal regions. Magnetic resonance imaging (MRI) documented in diffusion-weighted images (DWI) two areas of restricted diffusion in the left frontal and temporal cortex. After starting treatment with levetiracetam 3000. mg/day there was progressive recovery of the clinical picture as well as the gradual disappearance of the electroencephalographic seizure activity and the vanishing of areas of restricted diffusion in brain MRI. Based on the clinical, EEG and MRI data, we hypothesized that both aphasia and spasticity represented ictal signs. To our knowledge, this is the first case report of ictal spasticity.

Original languageEnglish
Pages (from-to)397-400
Number of pages4
JournalEpilepsy and Behavior
Volume25
Issue number3
DOIs
Publication statusPublished - Nov 2012

Fingerprint

Motor Neurons
etiracetam
Aphasia
Stroke
Magnetic Resonance Imaging
Temporal Lobe
Frontal Lobe
Electroencephalography
Seizures
Brain
Therapeutics

Keywords

  • Aphasia MRI DWI
  • EEG
  • Ictal spasticity
  • Status epilepticus

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology

Cite this

Liguori, C., Marciani, M. G., Albanese, M., Massa, R., Izzi, F., Placidi, F., ... Romigi, A. (2012). Spasticity as an ictal pattern due to excitotoxic upper motor neuron damage. Epilepsy and Behavior, 25(3), 397-400. https://doi.org/10.1016/j.yebeh.2012.08.026

Spasticity as an ictal pattern due to excitotoxic upper motor neuron damage. / Liguori, C.; Marciani, M. G.; Albanese, M.; Massa, R.; Izzi, F.; Placidi, F.; Mercuri, N. B.; Romigi, A.

In: Epilepsy and Behavior, Vol. 25, No. 3, 11.2012, p. 397-400.

Research output: Contribution to journalArticle

Liguori, C, Marciani, MG, Albanese, M, Massa, R, Izzi, F, Placidi, F, Mercuri, NB & Romigi, A 2012, 'Spasticity as an ictal pattern due to excitotoxic upper motor neuron damage', Epilepsy and Behavior, vol. 25, no. 3, pp. 397-400. https://doi.org/10.1016/j.yebeh.2012.08.026
Liguori C, Marciani MG, Albanese M, Massa R, Izzi F, Placidi F et al. Spasticity as an ictal pattern due to excitotoxic upper motor neuron damage. Epilepsy and Behavior. 2012 Nov;25(3):397-400. https://doi.org/10.1016/j.yebeh.2012.08.026
Liguori, C. ; Marciani, M. G. ; Albanese, M. ; Massa, R. ; Izzi, F. ; Placidi, F. ; Mercuri, N. B. ; Romigi, A. / Spasticity as an ictal pattern due to excitotoxic upper motor neuron damage. In: Epilepsy and Behavior. 2012 ; Vol. 25, No. 3. pp. 397-400.
@article{538fca172b6f46cb9d5944a94f796408,
title = "Spasticity as an ictal pattern due to excitotoxic upper motor neuron damage",
abstract = "We describe the case of a man who presented with spasticity and aphasia related to continuous electroencephalographic epileptic activity in the left frontal-temporal regions. Magnetic resonance imaging (MRI) documented in diffusion-weighted images (DWI) two areas of restricted diffusion in the left frontal and temporal cortex. After starting treatment with levetiracetam 3000. mg/day there was progressive recovery of the clinical picture as well as the gradual disappearance of the electroencephalographic seizure activity and the vanishing of areas of restricted diffusion in brain MRI. Based on the clinical, EEG and MRI data, we hypothesized that both aphasia and spasticity represented ictal signs. To our knowledge, this is the first case report of ictal spasticity.",
keywords = "Aphasia MRI DWI, EEG, Ictal spasticity, Status epilepticus",
author = "C. Liguori and Marciani, {M. G.} and M. Albanese and R. Massa and F. Izzi and F. Placidi and Mercuri, {N. B.} and A. Romigi",
year = "2012",
month = "11",
doi = "10.1016/j.yebeh.2012.08.026",
language = "English",
volume = "25",
pages = "397--400",
journal = "Epilepsy and Behavior",
issn = "1525-5050",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Spasticity as an ictal pattern due to excitotoxic upper motor neuron damage

AU - Liguori, C.

AU - Marciani, M. G.

AU - Albanese, M.

AU - Massa, R.

AU - Izzi, F.

AU - Placidi, F.

AU - Mercuri, N. B.

AU - Romigi, A.

PY - 2012/11

Y1 - 2012/11

N2 - We describe the case of a man who presented with spasticity and aphasia related to continuous electroencephalographic epileptic activity in the left frontal-temporal regions. Magnetic resonance imaging (MRI) documented in diffusion-weighted images (DWI) two areas of restricted diffusion in the left frontal and temporal cortex. After starting treatment with levetiracetam 3000. mg/day there was progressive recovery of the clinical picture as well as the gradual disappearance of the electroencephalographic seizure activity and the vanishing of areas of restricted diffusion in brain MRI. Based on the clinical, EEG and MRI data, we hypothesized that both aphasia and spasticity represented ictal signs. To our knowledge, this is the first case report of ictal spasticity.

AB - We describe the case of a man who presented with spasticity and aphasia related to continuous electroencephalographic epileptic activity in the left frontal-temporal regions. Magnetic resonance imaging (MRI) documented in diffusion-weighted images (DWI) two areas of restricted diffusion in the left frontal and temporal cortex. After starting treatment with levetiracetam 3000. mg/day there was progressive recovery of the clinical picture as well as the gradual disappearance of the electroencephalographic seizure activity and the vanishing of areas of restricted diffusion in brain MRI. Based on the clinical, EEG and MRI data, we hypothesized that both aphasia and spasticity represented ictal signs. To our knowledge, this is the first case report of ictal spasticity.

KW - Aphasia MRI DWI

KW - EEG

KW - Ictal spasticity

KW - Status epilepticus

UR - http://www.scopus.com/inward/record.url?scp=84868689004&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868689004&partnerID=8YFLogxK

U2 - 10.1016/j.yebeh.2012.08.026

DO - 10.1016/j.yebeh.2012.08.026

M3 - Article

C2 - 23103317

AN - SCOPUS:84868689004

VL - 25

SP - 397

EP - 400

JO - Epilepsy and Behavior

JF - Epilepsy and Behavior

SN - 1525-5050

IS - 3

ER -