Spatial and temporal EEG-fMRI changes during preictal and postictal phases in a patient with posttraumatic epilepsy

Silvia F. Storti, Alessandra Del Felice, Emanuela Formaggio, Ilaria Boscolo Galazzo, Luigi G. Bongiovanni, Roberto Cerini, Antonio Fiaschi, Paolo Manganotti

Research output: Contribution to journalArticlepeer-review

Abstract

The combined use of electroencephalography (EEG) and functional magnetic resonance imaging (EEG-fMRI) in epilepsy allows the noninvasive hemodynamic characterization of epileptic discharge-related neuronal activations. The aim of this study was to investigate pathophysiologic mechanisms underlying epileptic activity by exploring the spatial and temporal distribution of fMRI signal modifications during seizure in a single patient with posttraumatic epilepsy. EEG and fMRI data were acquired during two scanning sessions: a spontaneous critical episode was observed during the first, and interictal events were recorded during the second. The EEG-fMRI data were analyzed using the general linear model (GLM). Blood oxygenation level-dependent (BOLD) localization derived from the preictal and artifact-free postictal phase was concordant with the BOLD localization of the interictal epileptiform discharges identified in the second session, pointing to a left perilesional mesiofrontal area. Of note, BOLD signal modifications were already visible several seconds before seizure onset. In brief, BOLD activations from the preictal, postictal, and interictal epileptiform discharge analysis appear to be concordant with the clinically driven localization hypothesis, whereas a widespread network of activations is detected during the ictal phase in a partial seizure.

Original languageEnglish
Pages (from-to)247-252
Number of pages6
JournalClinical EEG and Neuroscience
Volume46
Issue number3
DOIs
Publication statusPublished - Jul 3 2015

Keywords

  • BOLD signal
  • ictal and postictal EEG-fMRI
  • interictal EEG-fMRI
  • posttraumatic epilepsy
  • seizure spread

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

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