Spatial discontinuities in human immunodeficiency virus type 1 quasispecies derived from epidermal Langerhans cells of a patient with AIDS and evidence for double infection

Monica Sala, Giovanna Zambruno, Jean Pierre Vartanian, Alessandra Marconi, Umberto Bertazzoni, Simon Wain-Hobson

Research output: Contribution to journalArticlepeer-review

Abstract

A nonhomogeneous spatial distribution of human immunodeficiency virus type 1 quasispecies was observed for epidermal Langerhans cells purified from skin patches taken from a patient with AIDS soon after death. Each patch presented a unique collection of sequences, distinct from those of juxtaposed patches or those derived from the other leg. Infection of Langerhans cells by virus from underlying T cells in the dermis might explain this partition. The analysis revealed the presence of two distinct cocirculating viral strains, indicating double infection.

Original languageEnglish
Pages (from-to)5280-5283
Number of pages4
JournalJournal of Virology
Volume68
Issue number8
Publication statusPublished - Aug 1994

ASJC Scopus subject areas

  • Immunology

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