Spatial learning and memory, maze running strategies and cholinergic mechanisms in two inbred strains of mice

Martine Ammassari-Teule, Antonio Caprioli

Research output: Contribution to journalArticlepeer-review

Abstract

The acquisition process of the radial maze task was studied in two inbred strains of mice, C57BL/6 and DBA/2. A quantitative and qualitative evaluation of performance was performed and the pretest level of activity was measured. The results showed a significant correlation between activity and performance since the highly active C57BL/6 mice exhibited better performance of the radial maze task than the less active DBA/2 mice. Moreover, for correct trials, strain-dependent maze-running strategies were observed: while both strains displayed about the same percentage of clockwise and spatial strategies, it was observed that among the spatial strategies C57BL/6 used a larger number of different correct solutions. Subsequently, the effect of scopolamine administration on working memory processes was assessed in sequential and discrete trials. A different reactivity of each strain to anti-cholinergic treatment was found in discrete trials since only DBA/2 mice were impaired. The effect of scopolamine is discussed in relation to the different models of information processing involved in learning and memorizing the experimental rule.

Original languageEnglish
Pages (from-to)9-16
Number of pages8
JournalBehavioural Brain Research
Volume17
Issue number1
DOIs
Publication statusPublished - 1985

Keywords

  • cholinergic mechanism
  • mouse
  • radial maze
  • spatial learning
  • spatial memory

ASJC Scopus subject areas

  • Behavioral Neuroscience

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