Spatial stimulus-response compatibility in callosotomy patients and subjects with callosal agenesis

S. Aglioti, G. Tassinari, G. Berlucchi

Research output: Contribution to journalArticlepeer-review

Abstract

Subjects with partial or complete defects of the corpus callosum, either congenital or acquired, performed a choice reaction time (RT) task involving a right or left key-press response to a light presented at random in the right or left visual hemifield. Like normal subjects, all of them exhibited two additive effects typical of these tasks: the spatial stimulus response compatibility effect (faster RT for stimuli and responses thatched for side), and the hand placement effect (longer RT for responses performed with crossed hands). Two subjects with a complete callosal defect, one acquired and the other congenital, showed a third effect, not present in normal subjects, consisting of a marked advantage for RT of responses with the hand anatomically ipsilateral to the stimulus, independent of both stimulus response compatibility and hand placement. These findings can be interpreted according to a hierarchical model of information processing assuming that, in the absence of the corpus callosum, the matching of the mental codes for the stimulus and response sets takes place solely in the hemisphere receiving the stimulus, with a subsequent rapid-intrahemispheric or slow-interhemispheric transmission of the response command to the appropriate motor centers.

Original languageEnglish
Pages (from-to)623-629
Number of pages7
JournalNeuroscience and Biobehavioral Reviews
Volume20
Issue number4
DOIs
Publication statusPublished - 1996

Keywords

  • Callosal agenesis
  • Callosotomy
  • Choice reaction time
  • Stimulus-response compatibility

ASJC Scopus subject areas

  • Behavioral Neuroscience

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