Spatio-temporal anomalous diffusion imaging: Results in controlled phantoms and in excised human meningiomas

Silvia Capuani, Marco Palombo, Andrea Gabrielli, Augusto Orlandi, Bruno Maraviglia, Francesco S. Pastore

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Recently, we measured two anomalous diffusion (AD) parameters: the spatial and the temporal AD indices, called γ and α, respectively, by using spectroscopic pulse gradient field methods. We showed that γ quantifies pseudo-superdiffusion processes, while α quantifies subdiffusion processes. Here, we propose γ and α maps obtained in a controlled heterogeneous phantom, comprised of packed micro-beads in water and in excised human meningiomas. In few words, α maps represent the multi-scale spatial distribution of the disorder degree in the system, while γ maps are influenced by local internal gradients, thus highlighting the interface between compartments characterized by different magnetic susceptibility. γ maps were already obtained by means of AD stretched exponential imaging and α-type maps have been recently achieved for fixed rat brain with the aim of highlighting the fractal dimension of specific brain regions. However, to our knowledge, the maps representative of the spatial distribution of α and γ obtained on the same controlled sample and in the same excised tissue have never been compared. Moreover, we show here, for the first time, that α maps are representative of the spatial distribution of the disorder degree of the system.In a first phase, γ and α maps of controlled phantom characterized by an ordered and a disordered rearrangement of packed micro-beads of different sizes in water and by different magnetic susceptibility (δχ) between beads and water were obtained. In a second phase, we investigated excised human meningiomas of different consistency.Results reported here, obtained at 9.4. T, show that α and γ maps are characterized by a different image contrast. Indeed, unlike γ maps, α maps are insensible to (δχ) and they are sensible to the disorder degree of the microstructural rearrangement. These observations strongly suggest that AD indices α and γ reflect some additional microstructural information which cannot be obtained using conventional diffusion methods based on Gaussian diffusion. Moreover, α and γ maps obtained in excised meningiomas seem to provide more microstructural details above those obtained with conventional DTI analysis, which could be used to improve the classification of meningiomas based on their consistency.

Original languageEnglish
Pages (from-to)359-365
Number of pages7
JournalMagnetic Resonance Imaging
Volume31
Issue number3
DOIs
Publication statusPublished - Apr 2013

Fingerprint

Meningioma
Imaging techniques
Water
Spatial distribution
Fractals
Brain
Magnetic susceptibility
Fractal dimension
Rats
Tissue

Keywords

  • Anomalous diffusion
  • Diffusion time variable PGSTE
  • Disorder degree
  • Magnetic susceptibility differences
  • Meningiomas
  • Non-Gaussian diffusion
  • Polystyrene micro-beads
  • Stretched exponential model

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Biomedical Engineering

Cite this

Spatio-temporal anomalous diffusion imaging : Results in controlled phantoms and in excised human meningiomas. / Capuani, Silvia; Palombo, Marco; Gabrielli, Andrea; Orlandi, Augusto; Maraviglia, Bruno; Pastore, Francesco S.

In: Magnetic Resonance Imaging, Vol. 31, No. 3, 04.2013, p. 359-365.

Research output: Contribution to journalArticle

Capuani, S, Palombo, M, Gabrielli, A, Orlandi, A, Maraviglia, B & Pastore, FS 2013, 'Spatio-temporal anomalous diffusion imaging: Results in controlled phantoms and in excised human meningiomas', Magnetic Resonance Imaging, vol. 31, no. 3, pp. 359-365. https://doi.org/10.1016/j.mri.2012.08.012
Capuani, Silvia ; Palombo, Marco ; Gabrielli, Andrea ; Orlandi, Augusto ; Maraviglia, Bruno ; Pastore, Francesco S. / Spatio-temporal anomalous diffusion imaging : Results in controlled phantoms and in excised human meningiomas. In: Magnetic Resonance Imaging. 2013 ; Vol. 31, No. 3. pp. 359-365.
@article{f82fb4f1335e4a4caf5b175cff97eef3,
title = "Spatio-temporal anomalous diffusion imaging: Results in controlled phantoms and in excised human meningiomas",
abstract = "Recently, we measured two anomalous diffusion (AD) parameters: the spatial and the temporal AD indices, called γ and α, respectively, by using spectroscopic pulse gradient field methods. We showed that γ quantifies pseudo-superdiffusion processes, while α quantifies subdiffusion processes. Here, we propose γ and α maps obtained in a controlled heterogeneous phantom, comprised of packed micro-beads in water and in excised human meningiomas. In few words, α maps represent the multi-scale spatial distribution of the disorder degree in the system, while γ maps are influenced by local internal gradients, thus highlighting the interface between compartments characterized by different magnetic susceptibility. γ maps were already obtained by means of AD stretched exponential imaging and α-type maps have been recently achieved for fixed rat brain with the aim of highlighting the fractal dimension of specific brain regions. However, to our knowledge, the maps representative of the spatial distribution of α and γ obtained on the same controlled sample and in the same excised tissue have never been compared. Moreover, we show here, for the first time, that α maps are representative of the spatial distribution of the disorder degree of the system.In a first phase, γ and α maps of controlled phantom characterized by an ordered and a disordered rearrangement of packed micro-beads of different sizes in water and by different magnetic susceptibility (δχ) between beads and water were obtained. In a second phase, we investigated excised human meningiomas of different consistency.Results reported here, obtained at 9.4. T, show that α and γ maps are characterized by a different image contrast. Indeed, unlike γ maps, α maps are insensible to (δχ) and they are sensible to the disorder degree of the microstructural rearrangement. These observations strongly suggest that AD indices α and γ reflect some additional microstructural information which cannot be obtained using conventional diffusion methods based on Gaussian diffusion. Moreover, α and γ maps obtained in excised meningiomas seem to provide more microstructural details above those obtained with conventional DTI analysis, which could be used to improve the classification of meningiomas based on their consistency.",
keywords = "Anomalous diffusion, Diffusion time variable PGSTE, Disorder degree, Magnetic susceptibility differences, Meningiomas, Non-Gaussian diffusion, Polystyrene micro-beads, Stretched exponential model",
author = "Silvia Capuani and Marco Palombo and Andrea Gabrielli and Augusto Orlandi and Bruno Maraviglia and Pastore, {Francesco S.}",
year = "2013",
month = "4",
doi = "10.1016/j.mri.2012.08.012",
language = "English",
volume = "31",
pages = "359--365",
journal = "Magnetic Resonance Imaging",
issn = "0730-725X",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Spatio-temporal anomalous diffusion imaging

T2 - Results in controlled phantoms and in excised human meningiomas

AU - Capuani, Silvia

AU - Palombo, Marco

AU - Gabrielli, Andrea

AU - Orlandi, Augusto

AU - Maraviglia, Bruno

AU - Pastore, Francesco S.

PY - 2013/4

Y1 - 2013/4

N2 - Recently, we measured two anomalous diffusion (AD) parameters: the spatial and the temporal AD indices, called γ and α, respectively, by using spectroscopic pulse gradient field methods. We showed that γ quantifies pseudo-superdiffusion processes, while α quantifies subdiffusion processes. Here, we propose γ and α maps obtained in a controlled heterogeneous phantom, comprised of packed micro-beads in water and in excised human meningiomas. In few words, α maps represent the multi-scale spatial distribution of the disorder degree in the system, while γ maps are influenced by local internal gradients, thus highlighting the interface between compartments characterized by different magnetic susceptibility. γ maps were already obtained by means of AD stretched exponential imaging and α-type maps have been recently achieved for fixed rat brain with the aim of highlighting the fractal dimension of specific brain regions. However, to our knowledge, the maps representative of the spatial distribution of α and γ obtained on the same controlled sample and in the same excised tissue have never been compared. Moreover, we show here, for the first time, that α maps are representative of the spatial distribution of the disorder degree of the system.In a first phase, γ and α maps of controlled phantom characterized by an ordered and a disordered rearrangement of packed micro-beads of different sizes in water and by different magnetic susceptibility (δχ) between beads and water were obtained. In a second phase, we investigated excised human meningiomas of different consistency.Results reported here, obtained at 9.4. T, show that α and γ maps are characterized by a different image contrast. Indeed, unlike γ maps, α maps are insensible to (δχ) and they are sensible to the disorder degree of the microstructural rearrangement. These observations strongly suggest that AD indices α and γ reflect some additional microstructural information which cannot be obtained using conventional diffusion methods based on Gaussian diffusion. Moreover, α and γ maps obtained in excised meningiomas seem to provide more microstructural details above those obtained with conventional DTI analysis, which could be used to improve the classification of meningiomas based on their consistency.

AB - Recently, we measured two anomalous diffusion (AD) parameters: the spatial and the temporal AD indices, called γ and α, respectively, by using spectroscopic pulse gradient field methods. We showed that γ quantifies pseudo-superdiffusion processes, while α quantifies subdiffusion processes. Here, we propose γ and α maps obtained in a controlled heterogeneous phantom, comprised of packed micro-beads in water and in excised human meningiomas. In few words, α maps represent the multi-scale spatial distribution of the disorder degree in the system, while γ maps are influenced by local internal gradients, thus highlighting the interface between compartments characterized by different magnetic susceptibility. γ maps were already obtained by means of AD stretched exponential imaging and α-type maps have been recently achieved for fixed rat brain with the aim of highlighting the fractal dimension of specific brain regions. However, to our knowledge, the maps representative of the spatial distribution of α and γ obtained on the same controlled sample and in the same excised tissue have never been compared. Moreover, we show here, for the first time, that α maps are representative of the spatial distribution of the disorder degree of the system.In a first phase, γ and α maps of controlled phantom characterized by an ordered and a disordered rearrangement of packed micro-beads of different sizes in water and by different magnetic susceptibility (δχ) between beads and water were obtained. In a second phase, we investigated excised human meningiomas of different consistency.Results reported here, obtained at 9.4. T, show that α and γ maps are characterized by a different image contrast. Indeed, unlike γ maps, α maps are insensible to (δχ) and they are sensible to the disorder degree of the microstructural rearrangement. These observations strongly suggest that AD indices α and γ reflect some additional microstructural information which cannot be obtained using conventional diffusion methods based on Gaussian diffusion. Moreover, α and γ maps obtained in excised meningiomas seem to provide more microstructural details above those obtained with conventional DTI analysis, which could be used to improve the classification of meningiomas based on their consistency.

KW - Anomalous diffusion

KW - Diffusion time variable PGSTE

KW - Disorder degree

KW - Magnetic susceptibility differences

KW - Meningiomas

KW - Non-Gaussian diffusion

KW - Polystyrene micro-beads

KW - Stretched exponential model

UR - http://www.scopus.com/inward/record.url?scp=84875270729&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875270729&partnerID=8YFLogxK

U2 - 10.1016/j.mri.2012.08.012

DO - 10.1016/j.mri.2012.08.012

M3 - Article

C2 - 23102948

AN - SCOPUS:84875270729

VL - 31

SP - 359

EP - 365

JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

SN - 0730-725X

IS - 3

ER -