Special considerations for the treatment of chronic kidney disease in the elderly

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Chronic kidney disease (CKD) is common in older adults, and its burden is expected to increase in older populations. Even if the knowledge on the approach to older patient with CKD is still evolving, current guidelines for pharmacological management of CKD does not include specific recommendations for older patients. Additionally, decision-making on renal replacement therapy (RRT) for older patients is far from being evidence-based, and despite the improvement in dialysis outcomes, RRT may cause more harm than benefit compared with conservative care when prognostic stratification is not carefully assessed. The use of comprehensive geriatric assessment tools could help clinicians in applying a more informed decision-making. Finally, physical exercise and rehabilitation interventions also represents a promising therapeutic strategy.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalExpert Review of Clinical Pharmacology
DOIs
Publication statusAccepted/In press - 2016

Fingerprint

Chronic Renal Insufficiency
Renal Replacement Therapy
Decision Making
Geriatric Assessment
Dialysis
Therapeutics
Rehabilitation
Pharmacology
Guidelines
Exercise
Population

Keywords

  • acidosis
  • albuminuria
  • anemia
  • Chronic kidney disease
  • comprehensive geriatric assessment
  • diabetes
  • hypertension
  • osteoporosis
  • rehabilitation
  • renal replacement therapy

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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title = "Special considerations for the treatment of chronic kidney disease in the elderly",
abstract = "Chronic kidney disease (CKD) is common in older adults, and its burden is expected to increase in older populations. Even if the knowledge on the approach to older patient with CKD is still evolving, current guidelines for pharmacological management of CKD does not include specific recommendations for older patients. Additionally, decision-making on renal replacement therapy (RRT) for older patients is far from being evidence-based, and despite the improvement in dialysis outcomes, RRT may cause more harm than benefit compared with conservative care when prognostic stratification is not carefully assessed. The use of comprehensive geriatric assessment tools could help clinicians in applying a more informed decision-making. Finally, physical exercise and rehabilitation interventions also represents a promising therapeutic strategy.",
keywords = "acidosis, albuminuria, anemia, Chronic kidney disease, comprehensive geriatric assessment, diabetes, hypertension, osteoporosis, rehabilitation, renal replacement therapy",
author = "Andrea Corsonello and Sergio Fusco and Silvia Bustacchini and Carlos Chiatti and Raffaella Moresi and Bonfigli, {Anna Rita} and {Di Stefano}, Giuseppina and Fabrizia Lattanzio",
year = "2016",
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T1 - Special considerations for the treatment of chronic kidney disease in the elderly

AU - Corsonello, Andrea

AU - Fusco, Sergio

AU - Bustacchini, Silvia

AU - Chiatti, Carlos

AU - Moresi, Raffaella

AU - Bonfigli, Anna Rita

AU - Di Stefano, Giuseppina

AU - Lattanzio, Fabrizia

PY - 2016

Y1 - 2016

N2 - Chronic kidney disease (CKD) is common in older adults, and its burden is expected to increase in older populations. Even if the knowledge on the approach to older patient with CKD is still evolving, current guidelines for pharmacological management of CKD does not include specific recommendations for older patients. Additionally, decision-making on renal replacement therapy (RRT) for older patients is far from being evidence-based, and despite the improvement in dialysis outcomes, RRT may cause more harm than benefit compared with conservative care when prognostic stratification is not carefully assessed. The use of comprehensive geriatric assessment tools could help clinicians in applying a more informed decision-making. Finally, physical exercise and rehabilitation interventions also represents a promising therapeutic strategy.

AB - Chronic kidney disease (CKD) is common in older adults, and its burden is expected to increase in older populations. Even if the knowledge on the approach to older patient with CKD is still evolving, current guidelines for pharmacological management of CKD does not include specific recommendations for older patients. Additionally, decision-making on renal replacement therapy (RRT) for older patients is far from being evidence-based, and despite the improvement in dialysis outcomes, RRT may cause more harm than benefit compared with conservative care when prognostic stratification is not carefully assessed. The use of comprehensive geriatric assessment tools could help clinicians in applying a more informed decision-making. Finally, physical exercise and rehabilitation interventions also represents a promising therapeutic strategy.

KW - acidosis

KW - albuminuria

KW - anemia

KW - Chronic kidney disease

KW - comprehensive geriatric assessment

KW - diabetes

KW - hypertension

KW - osteoporosis

KW - rehabilitation

KW - renal replacement therapy

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