TY - JOUR
T1 - Special issues in fertility preservation for gynecologic malignancies
AU - Tomao, Federica
AU - Peccatori, Fedro Alessandro
AU - Del Pup, Lino
AU - Franchi, Dorella
AU - Zanagnolo, Vanna
AU - Panici, Pierluigi Benedetti
AU - Colombo, Nicoletta
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Gynecologic malignancies account for 1,09 million new cancer cases worldwide consisting of about 12% of tumors affecting female population. About 10% of all female cancer survivors are younger than 40 years of age. Since cancers affecting female genital organs are usually treated by radical surgery, chemotherapy or chemoradiation approaches that induce permanent damage of reproductive functions, the development of strategies for fertility preservation represent one of the most important goals for gynecologic oncology. In this scenario, the newly defined oncofertility discipline acquires increasing interest, offering patients maximal chances to make an adequate decision about future fertility, based on their oncologic diagnosis and prognosis. However, the majority of physicians do not pay particular attention to these issues, even if impressive progresses have been made in this field in the last decades. Possibly, it is due to the lack of strong evidences from clinical trials without an adequate number of cases to establish safety and efficacy of these procedures. In this review we will discuss the most recently debated options for fertility preservation in gynecologic oncology, highlighting issues and controversies related to oncofertility.
AB - Gynecologic malignancies account for 1,09 million new cancer cases worldwide consisting of about 12% of tumors affecting female population. About 10% of all female cancer survivors are younger than 40 years of age. Since cancers affecting female genital organs are usually treated by radical surgery, chemotherapy or chemoradiation approaches that induce permanent damage of reproductive functions, the development of strategies for fertility preservation represent one of the most important goals for gynecologic oncology. In this scenario, the newly defined oncofertility discipline acquires increasing interest, offering patients maximal chances to make an adequate decision about future fertility, based on their oncologic diagnosis and prognosis. However, the majority of physicians do not pay particular attention to these issues, even if impressive progresses have been made in this field in the last decades. Possibly, it is due to the lack of strong evidences from clinical trials without an adequate number of cases to establish safety and efficacy of these procedures. In this review we will discuss the most recently debated options for fertility preservation in gynecologic oncology, highlighting issues and controversies related to oncofertility.
KW - Borderline ovarian tumor
KW - Cervical cancer
KW - Endometrial cancer
KW - Fertility sparing
KW - Malignant ovarian germ cell tumors
KW - Ovarian cancer
KW - Uterus transplantation
UR - http://www.scopus.com/inward/record.url?scp=84952638386&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84952638386&partnerID=8YFLogxK
U2 - 10.1016/j.critrevonc.2015.08.024
DO - 10.1016/j.critrevonc.2015.08.024
M3 - Article
VL - 97
SP - 206
EP - 219
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
SN - 1040-8428
ER -