Abstract
Inflammatory responses to microbial and non-microbial stimuli involve coordinate changes in the expression of hundreds of genes. The inflammatory gene expression programs display two important features: first, alternative stimuli affect both a large set of common genes and a variable number of stimulus-specific genes. Second, different genes are activated with different kinetics over several hours after the initial stimulus. Mechanistically, these features reflect the interplay between two main groups of determinants: the combinatorial control of transcription by multiple transcription factors, with NF-κB and the IRFs playing a central and essential role in the induction of a large fraction of inflammatory genes; and the presence of well-defined, in part cell-type specific, patterns of chromatin organization at cis-regulatory regions of inflammatory genes. Recent advancements in this field are providing paradigms of general value explaining how inducible responses to environmental stimuli are controlled.
Original language | English |
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Pages (from-to) | 61-72 |
Number of pages | 12 |
Journal | Current Topics in Microbiology and Immunology |
Volume | 349 |
DOIs | |
Publication status | Published - 2011 |
ASJC Scopus subject areas
- Immunology and Allergy
- Microbiology (medical)
- Immunology
- Microbiology