Species difference in diazepam metabolism and anticonvulsant effect

F. Marcucci, A. Guaitani, J. Kvetina, E. Mussini, S. Garattini

Research output: Contribution to journalArticlepeer-review

Abstract

Diazepam showed an antimetrazol activity which was longer-lasting in mice than in rats. The levels of diazepam in blood and brain were similar in both species but N-desmethyl metabolites ofdiazepam accumulated in mouse brain while they were practically undetectable in rat brain. The three main metabolites of diazepam, namely N-methyloxazepam, N-desmethyldiazepam and oxazepam showed strong anticonvulsant activity in mice.

Original languageEnglish
Pages (from-to)467-470
Number of pages4
JournalEuropean Journal of Pharmacology
Volume4
Issue number4
Publication statusPublished - Nov 1968

Keywords

  • Anticonvulsant activity
  • Diazepam
  • Diazepam blood level
  • Diazepam brain level
  • Metrazol
  • N-desmethyldiazepam
  • N-Methyloxazepam
  • Oxazepam

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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