TY - JOUR
T1 - Species differences in the role of excitatory amino acids in experimental parkinsonism
AU - Fornai, F.
AU - Vaglini, F.
AU - Maggio, R.
AU - Bonuccelli, U.
AU - Corsini, G. U.
PY - 1997
Y1 - 1997
N2 - The present review discusses species differences in relation to the effects produced by the neurotoxin 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP); in particular, it focuses on recent evidence regarding the role of excitatory amino acids in experimental parkinsonism. The main aim of the review is to provide a phylogenetic perspective which may serve as a useful tool to study Parkinson's disease in rodents. Excitotoxicity might represent the final common pathway on which the actions of different neurotoxins, selectively directed towards nigrostriatal dompaminergic neurons, converge. This is clearly demonstrated in methamphetamine- and 6-dihydroxy-dopamine-induced parkinsonism. The role of excitotoxicity in the mechanism of action of MPTP is less clear. Although there are several species differences for MPTP it is possible to obtain in mice the same effects induced in MPTP-treated primates by combining acetaldehyde or diethyldithiocarbamate with MPTP administration. When mice are administered these combined treatments, the onset of experimental parkinsonism can be prevented using the same pharmacological agents (i.e. glutamate N-methyl-D-aspartate antagonists) that are effective in primates.
AB - The present review discusses species differences in relation to the effects produced by the neurotoxin 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP); in particular, it focuses on recent evidence regarding the role of excitatory amino acids in experimental parkinsonism. The main aim of the review is to provide a phylogenetic perspective which may serve as a useful tool to study Parkinson's disease in rodents. Excitotoxicity might represent the final common pathway on which the actions of different neurotoxins, selectively directed towards nigrostriatal dompaminergic neurons, converge. This is clearly demonstrated in methamphetamine- and 6-dihydroxy-dopamine-induced parkinsonism. The role of excitotoxicity in the mechanism of action of MPTP is less clear. Although there are several species differences for MPTP it is possible to obtain in mice the same effects induced in MPTP-treated primates by combining acetaldehyde or diethyldithiocarbamate with MPTP administration. When mice are administered these combined treatments, the onset of experimental parkinsonism can be prevented using the same pharmacological agents (i.e. glutamate N-methyl-D-aspartate antagonists) that are effective in primates.
KW - Dopamine
KW - Excitatory amino acid
KW - Experimental parkinsonism
KW - Methamphetamine
KW - MPTP
KW - Nigrostriatal pathway
KW - NMDA-antagonists
UR - http://www.scopus.com/inward/record.url?scp=0031006956&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031006956&partnerID=8YFLogxK
U2 - 10.1016/S0149-7634(96)00042-5
DO - 10.1016/S0149-7634(96)00042-5
M3 - Article
C2 - 9195598
AN - SCOPUS:0031006956
VL - 21
SP - 401
EP - 415
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
SN - 0149-7634
IS - 4
ER -