Species differences in the role of excitatory amino acids in experimental parkinsonism

F. Fornai, F. Vaglini, R. Maggio, U. Bonuccelli, G. U. Corsini

Research output: Contribution to journalArticlepeer-review

Abstract

The present review discusses species differences in relation to the effects produced by the neurotoxin 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP); in particular, it focuses on recent evidence regarding the role of excitatory amino acids in experimental parkinsonism. The main aim of the review is to provide a phylogenetic perspective which may serve as a useful tool to study Parkinson's disease in rodents. Excitotoxicity might represent the final common pathway on which the actions of different neurotoxins, selectively directed towards nigrostriatal dompaminergic neurons, converge. This is clearly demonstrated in methamphetamine- and 6-dihydroxy-dopamine-induced parkinsonism. The role of excitotoxicity in the mechanism of action of MPTP is less clear. Although there are several species differences for MPTP it is possible to obtain in mice the same effects induced in MPTP-treated primates by combining acetaldehyde or diethyldithiocarbamate with MPTP administration. When mice are administered these combined treatments, the onset of experimental parkinsonism can be prevented using the same pharmacological agents (i.e. glutamate N-methyl-D-aspartate antagonists) that are effective in primates.

Original languageEnglish
Pages (from-to)401-415
Number of pages15
JournalNeuroscience and Biobehavioral Reviews
Volume21
Issue number4
DOIs
Publication statusPublished - 1997

Keywords

  • Dopamine
  • Excitatory amino acid
  • Experimental parkinsonism
  • Methamphetamine
  • MPTP
  • Nigrostriatal pathway
  • NMDA-antagonists

ASJC Scopus subject areas

  • Behavioral Neuroscience

Fingerprint Dive into the research topics of 'Species differences in the role of excitatory amino acids in experimental parkinsonism'. Together they form a unique fingerprint.

Cite this