Specific activation of B-cell clones within the central nervous system in course of herpes simplex encephalitis.

M. Ceroni, C. Camana, D. M. Franciotta, G. Bolelli, M. G. Revello, G. Gerna, F. Savoldi

Research output: Contribution to journalArticlepeer-review

Abstract

Total and virus-specific immunoglobulin (Ig) G oligoclonal bands were studied in paired serum and cerebrospinal fluid (CSF) of four patients with herpes simplex virus type 1 (HSV-1) encephalitis. We used the isoelectric focusing in agarose gel, a sensitive technique for protein separation, followed by passive transfer of proteins on nitrocellulose paper and specific immunostaining. Oligoclonal bands were observed in serum and CSF of all patients. HSV-1-specific oligoclonal IgG bands were present in the CSF only during a limited period of the disease, having their counterpart in serum during the remaining periods. Our findings contribute to tackle the issue of B-cell activation within central nervous system and peripheral blood compartments in course of HSV-1 encephalitis.

Original languageEnglish
Pages (from-to)1223-1230
Number of pages8
JournalBollettino della Societa Italiana di Biologia Sperimentale
Volume66
Issue number12
Publication statusPublished - Dec 1990

ASJC Scopus subject areas

  • Medicine(all)

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